Results 231 to 240 of about 8,847,117 (288)

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Kienbock's Disease and the Risk Factors Associated with Reoperation: A SPARCS Database Review over 10 Years. [PDF]

J Wrist Surg
Abola MV, Anil U, Lin CC, Richardson M, Gonzalez M, Smith L, Yang SS.   +6 more
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

The Point of No Return? Impediments to Return to Work for Injured Migrant Agricultural Workers in Two Canadian Provinces. [PDF]

New Solut
Mayell S, McLaughlin J, Hennebry J, Sanchez GV, Goswami P, Hanley J.   +5 more
europepmc   +1 more source

Cow-Related Injuries in Wisconsin During 2017-2023. [PDF]

Am J Ind Med
Modji KKS, McCoy K, Creswell PD, Collin MR, Tomasallo C, Bedno S.   +5 more
europepmc   +1 more source

Policy Analysis of Canadian Occupational Health and Safety Legislation and Regulations: Workplace Protections for Reproductive Health and Fetal Development. [PDF]

New Solut
Jahel F, Phillips KP.
europepmc   +1 more source

Trends in Outpatient Primary Total Hip and Knee Replacement From the Hospital Outpatient Department and Ambulatory Surgery Center Settings in New York State. [PDF]

Arthroplast Today
Ailaney N, Schloemann DT, Wegman SJ, Umelo J, Thirukumaran CP, Ricciardi BF.   +5 more
europepmc   +1 more source

Proposed flowchart for the management of suspected work-related mental disorders: an experience report. [PDF]

Rev Bras Med Trab
Dias ACS, Gonçalves RE.
europepmc   +1 more source

Healthcare Worker's Experiences of Patient-Initiated Workplace Violence in Emergency Departments: Qualitative Research. [PDF]

Nurs Open
Adhami N, Havaei F, Kaulius M, Teymourian R, Franke T, Naderi T, Abaya A, Alger K.   +7 more
europepmc   +1 more source

RETRACTION: Mechanism of p27 Upregulation Induced by Downregulation of Cathepsin B and Upar in Glioma

Molecular Oncology, EarlyView.
RETRACTION: S. Gopinath, K. Alapati, R. R. Malla, C. S. Gondi, S. Mohanam, D. H. Dinh, and J. S. Rao, “Mechanism of p27 Upregulation Induced by Downregulation of Cathepsin B and Upar in Glioma,” Molecular Oncology 5, no. 5 (2011): 426–437, https://doi.org/10.1016/j.molonc.2011.07.004.
wiley   +1 more source