Results 241 to 250 of about 1,690,790 (315)

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Nesting strategy reflects individual worker movement in termites. [PDF]

Mov Ecol
Kikuchi K, Bourguignon T, Mizumoto N.
europepmc   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Effectiveness and value of relationships in link worker social prescribing over an 18-month follow up period. [PDF]

BMC Prim Care
Sharman LS, Hayes S, Chua D, Haslam C, Cruwys T, Jetten J, Haslam SA, McNamara N, Baker JR, Johnson T, Dingle GA.   +10 more
europepmc   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Age, caste, and social context shape ovarian morphology and transcriptomic profiles in red harvester ants. [PDF]

NPJ Aging
Vergara-Martínez MF, Guerra-Sandoval D, Otero-Díaz B, Samacá-Sáenz E, Medina-Granados P, Reynoso-Robles R, Vigueras-Villaseñor RM, González-Maciel A, Fetter-Pruneda I.   +8 more
europepmc   +1 more source

Worker exposure to persistent organic pollutants, as polybrominated diphenyl ethers, and biological hazards during the processing of waste upholstered domestic seating in Great Britain. [PDF]

Ann Work Expo Health
Gosling RJ, Simpson AT, Bailey C, Baldwin PEJ, Lord S.   +4 more
europepmc   +1 more source

Correction: Resilience, ingenuity, and identity: A multi-level analysis of the Filipino community health worker experience in rural and remote municipalities in the Philippines. [PDF]

PLOS Glob Public Health
De Mesa RYH, Hendrickson ZM, Tan-Lim CSC, Elepaño A, Fabian NMC, Lopez JFE, Latkin CA, Dans LF, Rey MP, Dans AML.   +9 more
europepmc   +1 more source