Integration of circadian and hypoxia signaling via non‐canonical heterodimerization
CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley +1 more source
Status of the profession of a teacher as a resource for increasing professional satisfaction
Based on the data of the sociological survey “Status of the Profession of a Teacher” conducted in the territory of Kemerovo Region since 2010, the authors analyze dynamics of the ideas of the region’s teachers about the status of their profession and ...
Olga G. Krasnoshlykova +3 more
doaj
Trends in Moral Injury, Distress, and Resilience Factors among Healthcare Workers at the Beginning of the COVID-19 Pandemic [PDF]
Stella E. Hines +3 more
openalex +1 more source
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley +1 more source
Uber drivers perception about their work and health conditions in the context of covid-19 in Brazil
João Pedro Greggo +3 more
doaj +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Status and Progress of Research on Metabolomics of Cervical Cancer
Cervical cancer is one of the most common gynecological malignant tumors in China. Given their lack of obviously early symptoms, more than half of patients with cervical cancer are diagnosed in the middle and late stages of this malignancy, resulting in ...
Shaojun CHEN +8 more
doaj +1 more source
Mobile crowdsourcing - activation of smartphones users to elicit specialized knowledge through worker profile match [PDF]
Oskar Jarczyk
openalex +1 more source
Fear of COVID-19 among Healthcare Workers: The Role of Neuroticism and Fearful Attachment [PDF]
Alfonso Troisi +4 more
openalex +1 more source

