Results 151 to 160 of about 1,284,641 (318)

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Work- and hydration-related health outcomes prevalence among USA construction workers: evidence from the national survey. [PDF]

Front Public Health
Idris MA, Gitter A, Deemer E, Zhang Y, Gao J.   +4 more
europepmc   +1 more source

Job Stress and Working Capacity among Fly-In-Fly-Out Workers in the Oil and Gas Extraction Industries in the Arctic [PDF]

, 2020
Yana Korneeva, Natalia Simonova
openalex   +1 more source

AGING WORKERS [PDF]

Occupational and Environmental Medicine, 2001
openaire   +2 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Online Community of Childcare Workers and Their Diverse Workstyles

ABIRU Kazuki
openalex   +2 more sources

Optimizing Test and Treat in Malawi: health care worker perspectives on barriers and facilitators to ART initiation among HIV-infected clients who feel healthy [PDF]

, 2020
Kathryn Dovel, Khumbo Phiri, Misheck Mphande, Deborah Mindry, Esnart Sanudi, Mcdaphton Bellos, Risa M. Hoffman   +6 more
openalex   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Digital technology, emotions, and social relationships in dementia care: A narrative review. [PDF]

Digit Health
Persson M, Bivall AC, Thunman E.
europepmc   +1 more source

Factors Influencing Mental Health of Medical Workers During the COVID-19 Outbreak [PDF]

, 2020
Yan Zhang, Simiao Xie, Pu Wang, Guixiang Wang, Li Zhang, Xiaochen Cao, Wenzhi Wu, Yueran Bian, Fei Huang, Na Luo, Mingyan Luo, Qiang Xiao   +11 more
openalex   +1 more source