Results 171 to 180 of about 4,630,847 (264)

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

The association of workplace psychosocial factors on premenstrual dysphoric disorder: A six-month prospective study on Japanese female workers. [PDF]

PCN Rep
Iida M, Watanabe K, Egawa M, Ito Y, Kanamori Y, Tsuji R, Nishi D, Sasaki N.   +7 more
europepmc   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Healthcare workers' knowledge, attitudes, perceptions and practices of noma in Northwest Nigeria: a cross-sectional study. [PDF]

BMJ Public Health
Olaleye M, Amirtharajah M, Farley E, Sherlock M, Samuel J, Malual M, Karinja MN, Enwerem K, Kabila D, Stringer B, Ariti C, Abdurrazaq T, Isah S, Adetunji AS, Saleh F, Ihekweazu C, Benyeogor E, Falq G.   +17 more
europepmc   +1 more source

Justice (Vol. 16, Iss. 5) [PDF]

, 1932
International Ladies Garment Workers Union (ILGWU)
core   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Roles and functions of social workers in long-term care for older adults in East and North-East Asia: a mixed-methods systematic review since 2000. [PDF]

Front Public Health
Liu X, Li J, Kim S.
europepmc   +1 more source

Justice (Vol. 31, Iss. 4) [PDF]

, 1949
International Ladies Garment Workers Union (ILGWU)
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Will 'Support at Home' Deliver What Older People Want? [PDF]

Australas J Ageing
Laragy C, McVilly K.
europepmc   +1 more source