Results 241 to 250 of about 1,284,641 (318)

Impact of interventions to prevent asbestos-related respiratory disease in an exposed worker registry using a simplified G-computation. [PDF]

Am J Epidemiol
DeBono NL, Everest L, Richardson DB, Berriault C, Yeo RE, Meeds MA, Arrandale V, Demers PA.   +7 more
europepmc   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Redox regulation meets metabolism: targeting PRDX2 to prevent hepatocellular carcinoma

Molecular Oncology, EarlyView.
PRDX2 acts as a central redox hub linking metabolic dysfunction‐associated steatohepatitis (MASH) to hepatocellular carcinoma (HCC). In normal hepatocytes, PRDX2 maintains redox balance and metabolic homeostasis under oxidative stress. In contrast, during malignant transformation, PRDX2 promotes oncogenic signaling, stemness, and tumor initiation ...
Naroa Goikoetxea‐Usandizaga, María Luz Martinez‐Chantar, Carolina Conter   +2 more
wiley   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

How to design decision-support tools for primary healthcare using a human-centred design approach: the processes and experience of PHISICC in three Sub-Saharan countries. [PDF]

BMJ Glob Health
Rodriguez Franco D, Co-creation groups, Auer C, Zuske MK, Oyo-Ita A, Muloliwa A, Yapi RB, Berté S, Samba M, Garba AB, Njepuome AN, Ekpenyong N, Matsinhe G, Brown D, Krause LK, Sacarlal J, Bosch-Capblanch X.   +16 more
europepmc   +1 more source

Inequitable morbidity and injuries burden among informal sector workers in an urban area in Dhaka: a retrospective analysis of Médecins Sans Frontières occupational health clinics, Bangladesh, 2014-2023. [PDF]

BMC Public Health
Caleo G, Sadique S, Malden D, Dada M, Joseph J, Velivela K, Chowdhury SM, Mayienga C, Shenjuti T, Sadacharamani G, Masum RR, Sherlock M, Atim H, Keating P.   +13 more
europepmc   +1 more source

Age and QMP exposure affect the nutritional preferences of caged Apis mellifera worker honeybees. [PDF]

Apidologie
Bracuti A, Hudson ZL, Pidcock EH, Yoon K, Duncan EJ.   +4 more
europepmc   +1 more source

The impact of the work organization on individuals' psychological well-being. [PDF]

Front Public Health
Riccardi E, Leso V, Fontana L, Fusco F, Coppola M, Pacella D, Iavicoli I.   +6 more
europepmc   +1 more source