Results 51 to 60 of about 1,073,227 (356)

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Investigation of the gas turbine engine combustion chamber workflow

Вестник Самарского университета: Аэрокосмическая техника, технологии и машиностроение, 2016
The article describes methods of investigation of the processes inside the combustion chamber of the gas turbine engine. The investigation is aimed at revealing changes in the combustion chamber workflow depending on the changes in the operating ...
A. N. Markushin, A. V. Baklanov
doaj   +1 more source

Integration of BPM systems [PDF]

, 2010
New technologies have emerged to support the global economy where for instance suppliers, manufactures and retailers are working together in order to minimise the cost and maximise efficiency. One of the technologies that has become a buzz word for many
Bacon, Liz, Caldera, Andrea, Ma, Chaoying, Petridis, Miltos, Windall, Gill   +4 more
core   +2 more sources

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

PaPaS: A Portable, Lightweight, and Generic Framework for Parallel Parameter Studies

, 2018
The current landscape of scientific research is widely based on modeling and simulation, typically with complexity in the simulation's flow of execution and parameterization properties.
Day, Judy, Lenhart, Suzanne, Peterson, Gregory D., Ponce, Eduardo, Stephenson, Brittany   +4 more
core   +1 more source

Engineering design optimization using services and workflows [PDF]

Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences, 2009
Multi-disciplinary design optimization (MDO) is the process whereby the often conflicting requirements of the different disciplines to the engineering design process attempts to converge upon a description that represents an acceptable compromise in the design space.
Crick, Tom, Dunning, Peter, Kim, Hyunsun, Padget, Julian   +3 more
openaire   +3 more sources

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Towards an aspect weaving BPEL engine [PDF]

, 2004
This position paper proposes the use of dynamic aspects and the visitor design pattern to obtain a highly configurable and extensible BPEL engine. Using these two techniques, the core of this infrastructural software can be customised to meet new ...
Courbis, C., Finkelstein, A.
core  

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Engineering Workflow: The Process in Product Data Technology [PDF]

, 2000
The prevailing paradigm for enterprises in the new decade is undoubtedly speed. This enterprise view is driven by the availability of e-business technology that enables new forms of collaboration between companies.
Bijwaard, D.J.A., Boer, P.T. de, Spee, J.B.R.M.   +2 more
core   +1 more source