Results 91 to 100 of about 7,297,432 (370)

Multi‐omic profiling of squamous cell lung cancer identifies metabolites and related genes associated with squamous cell carcinoma

Molecular Oncology, EarlyView.
Using multi‐omic characterization, we aimed to identify key regulators specific to squamous cell lung carcinoma (SqCC). SqCC‐specific differentially expressed genes were integrated with metabolics data. High expression of the creatine transporter SLC6A8, along with elevated creatine levels, appeared to be a distinct metabolic feature of SqCC.
Johan Staaf, Daniel Ehinger, Hans Brunnström, Mats Jönsson, Frida Rosengren, Marija Kotevska, Anna Karlsson, Mattias Aine, Christian Frezza, Maria Planck, Elsa Arbajian   +10 more
wiley   +1 more source

Shortcomings of learning design approaches and a possible way out [PDF]

, 2008
Shifting away from traditional instructional design to younger research streams like personalized, workflow-based or collaborative e-learning, learning design (LD) has become an important issue in the field of technology-enhanced learning.
Moedritscher, Felix, Wild, Fridolin
core  

A linked data approach to publishing complex scientific workflows [PDF]

, 2011
Past data management practices in many fields of natural science, including climate research, have focused primarily on the final research output - the research publication - with less attention paid to the chain of intermediate data results and their ...
Callaghan, Sarah, Harpham, Colin, Lawrence, Bryan, Matthews, Brian, Osborn, Timothy, Shaon, Arif, Woolf, Andrew   +6 more
core   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Health information technology and optimizing workflow in a teaching hospital [PDF]

Payesh
Objective(s): The implementation of health information systems in hospitals not only ensures more accurate record-keeping but also improves workflow.
Sajjad Dehghan, Ali Mohamamd Mosadeghrad, Alireza Atashi, Alireza Hajizadeh, Zeinab Khaledian, Maryam Tajvar   +5 more
doaj  

An architecture for bridging OO and business process modeling. [PDF]

Workflow systems and object-oriented (OO) technology have undoubtedly been some of the most important domains of interest of information technology over the past decade.
Dedene, Guido, Poelmans, Stephan, Snoeck, Monique   +2 more
core  

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Association of Virtual Nurses’ Workflow and Cognitive Fatigue During Inpatient Encounters: Cross-Sectional Study

JMIR Human Factors
BackgroundThe virtual nursing delivery model enables the provision of expert nursing care from a remote location, using technology such as audio and video communication, remote monitoring devices, and access to electronic health records.
Saif Khairat, Jennifer Morelli, Wan-Ting Liao, Julia Aucoin, Barbara S Edson, Cheryl B Jones   +5 more
doaj   +1 more source

A Taxonomy of Workflow Management Systems for Grid Computing

, 2005
With the advent of Grid and application technologies, scientists and engineers are building more and more complex applications to manage and process large data sets, and execute scientific experiments on distributed resources.
A. Geppert, D. Fernández-Baca, D. Gelernter, D. Thain, E. Deelman, G. Zheng, I. Taylor, Jia Yu, M. Addis, R. Wolski, Rajkumar Buyya, W.M.P. Aalst van der, W.M.P. Aalst van der   +12 more
core   +4 more sources