Results 51 to 60 of about 481,697 (339)

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

CrossFlow: Cross-Organizational Workflow Management for Service Outsourcing in Dynamic Virtual Enterprises [PDF]

, 2001
In this report, we present the approach to cross-organizational workflow management of the CrossFlow project. CrossFlow is a European research project aiming at the support of cross-organizational workflows in dynamic virtual enterprises. The cooperation
Aberer, Karl, Grefen, Paul, Hoffner, Yigal, Ludwig, Heiko   +3 more
core   +1 more source

Automated syntactic mediation for Web service integration

, 2006
As the Web Services and Grid community adopt Semantic Web technology, we observe a shift towards higher-level workflow composition and service discovery practices.
Moreau, Luc, Payne, Terry R, Szomszor, Martin   +2 more
core   +1 more source

PinAPL-Py: A comprehensive web-application for the analysis of CRISPR/Cas9 screens. [PDF]

, 2017
Large-scale genetic screens using CRISPR/Cas9 technology have emerged as a major tool for functional genomics. With its increased popularity, experimental biologists frequently acquire large sequencing datasets for which they often do not have an easy ...
Bath, Tyler, Esko, Jeffrey D, Harismendy, Olivier, Kim, Jihoon, Lewis, Nathan E, Spahn, Philipp N, Weiss, Ryan J   +6 more
core   +2 more sources

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Requirements for the workflow-based support of release management processes in the automotive sector [PDF]

, 2005
One of the challenges the automotive industry currently has to master is the complexity of the electrical/elctronic system of a car. One key factor for reaching short product development cycles and high quality in this area are well-defined, properly ...
Bestfleisch, U., Herbst, J., Reichert, M.U.   +2 more
core   +2 more sources

Integrating CRISPR-Cas9 Technology into Undergraduate Courses: Perspectives from a National Science Foundation (NSF) Workshop for Undergraduate Faculty, June 2018

Journal of Microbiology & Biology Education, 2019
As CRISPR (clustered regularly interspaced short palindromic repeats)-Cas9 technology becomes more mainstream in life science research, it becomes critical for undergraduate instructors to devise engaging ways to bring the technology into their ...
Michael J. Wolyniak, Shane Austin, Lucian F. Bloodworth, Dawn Carter, Scott H. Harrison, Tiffany Hoage, Lisa Hollis-Brown, Felicia Jefferson, Alison Krufka, Farida Safadi-Chamberlin, Maria S. Santisteban, Paula Soneral, Beth VanWinkle, Anil K. Challa   +13 more
doaj   +1 more source

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

What You Need to Know about Bar-Code Medication Administration [PDF]

, 2019
Medication errors are the most common type of preventable error. Bar-code medication administration (BCMA) technology was designed to reduce medication administration errors.
Kuhlmann, Martha, DNP, MSN, RN, FNP, PMHCNS-BC, APRN, McBee, Marie E, DNP, MSN, Patterson, Pam, DNP, MSN, NE-BC   +2 more
core   +1 more source