Results 111 to 120 of about 2,718,327 (306)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

"The Backward-bending Commute times of Married Women with Household Responsibility" [PDF]

Though the existing literature provides evidence that married women choose short commutes because of low wages and household responsibilities, this theoretical paper shows that wives employed in highly paid positions also undertake short commutes and ...
Keiko Tamada, Shinichiro Iwata
core  

Covariate Adjustment for the Intention-to-Treat Parameter with Empirical Efficiency Maximization [PDF]

, 2008
In randomized experiments, the intention-to-treat parameter is defined as the difference in expected outcomes between groups assigned to treatment and control arms.
Rubin, Daniel B., van der Laan, Mark J.
core   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Multi-person bargaining with complementarity: Is there holdout? [PDF]

This paper studies a non-cooperative bargaining problem with one buyer and many sellers, focussing on the tension between the complementarity intrinsic to such a setup and efficiency. We address this problem in a very general setup with a technology that
Kunal Sengupta, Prabal Roy Chowdhury
core   +3 more sources

The Proletarian Literature Movement: Japan’s First Encounter with Working-Class Literature

, 2020
This essay explores Japanese working-class literature as it developed within the wider context of the so-called Proletarian Cultural Movement that was in operation for about ten years, peaking in the late 1920s. While tracing the origins of the initiative to create a “proletarian” literature in Japan to Marxist study circles at universities, it ...
openaire   +2 more sources

Modes of production of working-class literature from Asia

, 2022
In recent years, we are witnessing a growing interest and urgency in the exploration of working-class literature. However, systematical and historical investigations of working-class literature are still rare in Asian countries. This dissertation aims to fill the gap by studying working-class literature from modern Singapore and China.
openaire   +2 more sources

Addressing Class Imbalance of Health Data: A Systematic Literature Review on Modified Synthetic Minority Oversampling Technique (SMOTE) Strategies

JOIV: International Journal on Informatics Visualization
The Synthetic Minority Oversampling Technique (SMOTE) method is the baseline for solving unbalanced data problems. The working concept of the SMOTE method is to generate new synthetic data patterns by performing linear interpolation between minority ...
Hairani Hairani, Triyanna Widiyaningtyas, Didik Dwi Prasetya   +2 more
semanticscholar   +1 more source