Results 131 to 140 of about 2,718,327 (306)
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Analyzing the JDP Era through Class Struggles
Siyasal: Journal of Political SciencesSeveral significant social changes have occurred during the 21-year tenure of the Justice and Development Party (JDP) government in Turkey. However, the scholarship on this period either utterly disregards the working class or depicts it as a passive ...
Mertcan Şafak Sağlam
doaj +1 more source
NEET in Essex: A Review of the Evidence [PDF]
, 2008 This report reviews the published research evidence on the factors and processes that lead some young people into becoming ?Not in Employment, Education or Training? (NEET), and the policy interventions that are deemed to prevent this. It also includes a
Stoneman, P, Thiel, D
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Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
abiti-lavoro: "working-class desire to write" between poetry and social demands
Rivista di Storia dell'EducazioneThe present work aims to explore, through the pages of abiti-lavoro, the rich and vital shadow zone represented by working-class poetry. The magazine, born in the 1980s has the remarkable feature of being founded, written, and "assembled" exclusively ...
Monica Dati
doaj +1 more source
Working‐class Latina/o youth navigating stratification and inequality: A review of literature
Sociology Compass, 2022 Stephanie L. Canizales +1 more
semanticscholar +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Negotiation and Navigation - an Exploration of the Spaces/Places of Working-Class Lesbians [PDF]
This article draws upon my research on working-class lesbians, which explores the relationship between class, sexuality and social exclusion. Research participants were drawn mainly from Scotland (Glasgow, Edinburgh and the Highlands), with smaller ...
Yvette Taylor
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Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source