Results 21 to 30 of about 519,666 (208)

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

open access: yesFEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes   +4 more
wiley   +1 more source

Modes of production of working-class literature from Asia

open access: yes, 2021
In recent years, we are witnessing a growing interest and urgency in the exploration of working-class literature. However, systematical and historical investigations of working-class literature are still rare in Asian countries. This dissertation aims to
Lei, Luka Zhang
core   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Literature and class : aesthetical-political strategies in modern Swedish working-class literature [PDF]

open access: yes, 2014
Boken behandlar, med utgångspunkt i marxistisk litteraturteori, hur klass skildras i modern svensk arbetarlitteratur. Särskild uppmärksamhet ägnas åt Folke Fridells Död mans hand och Greppet hårdnar, Göran Palms rapportböcker från LM Ericsson och ...
Nilsson, Magnus, Nilsson, Magnus,
core   +1 more source

Swedish working class literature and the class politics of heritage

open access: yes, 2011
Artikeln argumenterar för att framväxten av gruppspecifika kulturarv innebär en utmaning för idén om nationella kulturarv, men att konstruktionen av arbetarlitteratur som kulturarv också innebär ett utmanande av de hegemoniska identitetspolitiska ...
Nilsson, Magnus,
core   +2 more sources

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Working-Class Literature(s)

open access: yes
"Working-ClassLiterature(s)" provides a wide-ranging account of earlier theoretical models of working-class writing and an assessment of their achievements and limitations.
Nilsson, Magnus,
core   +1 more source

Towards a theory of working class literature : Lewis Grassic Gibbon's "A Scots quair" in the context of earlier working class writing [PDF]

open access: yes, 1992
The main aim of this thesis is to develop a theoretical approach to working class literature, up to and including the 1930's, in order to place Lewis Grassic Gibbon's A Scots Ouair within the context of working class writing.
Michael, Olivia
core  

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

open access: yesFEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil   +4 more
wiley   +1 more source

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