Results 131 to 140 of about 65,531 (253)

Cancer‐Associated BCL‐2 Mutants Reveal Mechanisms Towards Venetoclax Resistance

Advanced Science, EarlyView.
Venetoclax (VEN) resistance in chronic lymphocytic leukemia arises from diverse BCL2 mutations. We map mechanisms contributing to VEN resistance across common BCL‐2 variants. G101V and D103Y reduce drug binding and increase sequestration of pro‐apoptotic proteins. V156D blocks VEN allosterically.
Jonas Aufdermauer, Ian de Ridder, Mahjoobeh Ehsani, Marasim Khan, Justin Kale, Lukas P. Frenzel, David Andrews, Spyridoula Karamanou, Ana J. Garcia‐Saez, Geert Bultynck   +9 more
wiley   +1 more source

Working Alliance and Subjective Engagement with a Digital Avatar CBT Platform (RITch^®CBT): Comparing Young Adults with and Without Co-Occurring Substance Use and Depression. [PDF]

Behav Sci (Basel)
Pezzino V, Berbary C, McKinney C, Sangiorgio C, Moriuchi E, Klimczak KS, Cooper RK, Kniffen W, Hareli M, Crane C, Easton CJ.   +10 more
europepmc   +1 more source

Examining between- and within-person effects of the self-stigma of seeking psychological help on the therapeutic working alliance: The moderating role of psychological distress. [PDF]

Psychotherapy (Chic), 2023
Seidman AJ, Vogel DL, Lannin DG.
europepmc   +1 more source

Immediate Growth Control in Response to Boiling Histotripsy is Prognostic for Intratumoral Immune Activation

Advanced Science, EarlyView.
Boiling Histrotripsy (BH), a mechanical form of focused ultrasound (FUS), allows for non‐invasive and non‐ionizing tissue destruction. Utilizing a BH treatment protocol that yielded bifurcating primary tumor growth responses, we found that immediate BH‐induced tumor growth control identifies tumors with acute reductions in antigen‐presenting cells (APC)
Lydia E. Kitelinger, Matthew R. DeWitt, Carly M. Van Wagoner, Claire A. Conarroe, Charles C. Funk, Aaron B. Streit, AeRyon Kim, Richard J. Price, Timothy N. J. Bullock   +8 more
wiley   +1 more source

Corrigendum: Editorial: Working Dogs: Form and Function

Frontiers in Veterinary Science, 2020
Cynthia M. Otto, Cynthia M. Otto, Mia L. Cobb, Mia L. Cobb, Erik Wilsson   +4 more
doaj   +1 more source

Time Perspective Matters for Working Alliance in Schizophrenia Care: Insights From the DiAPAson Project. [PDF]

Clin Psychol Psychother
Zarbo C, Stolarski M, Martella D, Toffol E, de Girolamo G, DIAPASON consortium.   +5 more
europepmc   +1 more source

Programmable Chaotic Suspension Electrolysis for Scalable Manufacturing of Vacancy‐Tunable Electrolytic MnO2

Advanced Science, EarlyView.
Programmable chaotic suspension electrolysis bridges laboratory synthesis and industrial manufacturing of high‐performance MnO2 cathodes. This scalable strategy enables tunable oxygen vacancies and a robust γ/β tunnel framework, delivering superior electrochemical performance and thermal stability.
Zhihao Wu, Jie Yang, Yidan Fan, Wentao Li, Jiaxing Li, Jing Guo, Chunbiao Li, Lei Shi, Jiaoyuan Zhang, Xingna Cai, Zukang Chen, Qian Zhang, Jun Du, Changyuan Tao, Qizhi Chen, Guocan Zheng, Zuohua Liu   +16 more
wiley   +1 more source

Validating the working alliance inventory in a mobile health smoking cessation program: A quasi-experimental study among Mexican adults who smoke. [PDF]

Tob Induc Dis
Gallegos-Carrillo K, Ramírez-Palacios P, Chávez-Iñiguez A, Cupertino AP, Cartujano-Barrera F, Rodríguez-Bolaños R.   +5 more
europepmc   +1 more source

"I See What You Mean"-A Case Study of the Interactional Foundation of Building a Working Alliance in Care Decisions Involving an Older Couple Living with Cognitive Decline. [PDF]

Healthcare (Basel), 2023
Nilsson E, Olaison A.
europepmc   +1 more source

Ahcy Acts as an Effector of Hnf4a‐Driven Super‐Enhancer Activation to Alleviate MASLD During Intermittent Fasting

Advanced Science, EarlyView.
Our study identifies an Hnf4a‐driven super‐enhancer of hepatic Ahcy that mediates the protective effects of intermittent fasting against MASLD. Disruption of the Ahcy super‐enhancer reduces Ahcy expression and exacerbates lipid accumulation. This pathway prevents aberrant promoter hypermethylation by maintaining the SAM/SAH balance, as exemplified by ...
Huafeng Chen, Shilin Zhang, Xiaojie Deng, Wenqiang Xie, Fen Xu, Jie Shen, Hua Liang   +6 more
wiley   +1 more source