Results 191 to 200 of about 432,742 (265)

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Justification trajectories for pension inequality in Chile (2016-2023): the role of social class and beliefs in meritocracy. [PDF]

Front Sociol
Castillo JC, Canales-Sellés R, Laffert A, Urzúa T.   +3 more
europepmc   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Genetic Alterations Shaping the Functional Properties of DyP Peroxidases. [PDF]

ACS Omega
Saad MM, Habib MH, ElRakaiby MT, Mourad FE.   +3 more
europepmc   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Singlet-like correlations: equal peak work, unequal robustness. [PDF]

Eur Phys J Plus
Svozil K.
europepmc   +1 more source

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source

Between work and care: a comparative study of the trajectories of women from different social classes in Cuba and Argentina. [PDF]

Front Sociol
Muñiz Terra L, León DE, Companioni YB.
europepmc   +1 more source

Transforming climate change and health practice: a follow-up survey of participants in a global online professional education programme. [PDF]

BMJ Public Health
Rachman A, Sun Y, Babcock-Dunning L, Timm K, Dubrow R, Carrión D.   +5 more
europepmc   +1 more source

Impact of China's Drug Regulatory Reforms on the Development of Anti-Tumor Drugs. [PDF]

Cancer Commun (Lond)
Tang L, Yuan L, Geng Y, Yang Z, Huang G.
europepmc   +1 more source