Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
Class, gender and the work of working-class women amid turbulent times. [PDF]
Br J SociolWarren T, Torres L, Lyonette C, Tarlo R.
europepmc +1 more source
Workplace Policies and Mental Health among Working-Class, New Parents. [PDF]
Community Work Fam, 2017 Perry-Jenkins M +3 more
europepmc +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
A full-spectrum aqueous extract of black cardamom (<i>Amomum subulatum</i>) improves focus/alertness and executive function: a randomized, double-blinded, placebo- and active-controlled, comparative study in healthy working-class participants. [PDF]
Front NeurosciThomas JV +7 more
europepmc +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
"I'm a bit middle class, a bit working class, a bit white and a bit Caribbean" - the retention of nurses in general practice and the intersection of professional and societal level cultural and structural issues: a qualitative interview study. [PDF]
BMC Health Serv ResAnderson H, Brady L, Adamson J.
europepmc +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Affordable 3D Orientation Visualization Solution for Working Class Remotely Operated Vehicles (ROV). [PDF]
Sensors (Basel)Kasno MA, Yahaya IN, Jung JW.
europepmc +1 more source