Results 141 to 150 of about 15,854,076 (410)

Working Time and Work-Life Balance in a Life Course Perspective [PDF]

, 2012
[Excerpt] Since the 1980s, most industrial societies have experienced a marked trend towards the diversification, decentralisation and individualisation of working time patterns, driven both by companies’ needs for greater adaptability in order to meet ...
European Foundation for the Improvement of Living and Working Conditions
core   +1 more source

Peripheral blood proteome biomarkers distinguish immunosuppressive features of cancer progression

Molecular Oncology, EarlyView.
Immune status significantly influences cancer progression. This study used plasma proteomics to analyze benign 67NR and malignant 4T1 breast tumor models at early and late tumor stages. Immune‐related proteins–osteopontin (Spp1), lactotransferrin (Ltf), calreticulin (Calr) and peroxiredoxin 2 (Prdx2)–were associated with systemic myeloid‐derived ...
Yeon Ji Park, Jae Won Oh, Hyewon Chung, Jung Won Kwon, Yi Rang Na, Kwang Pyo Kim, Seung Hyeok Seok   +6 more
wiley   +1 more source

Economic conditions at the time of birth and cognitive abilities late in life: evidence from eleven European countries [PDF]

With ageing populations and a stronger reliance on individual financial decision-making concerning asset portfolios, retirement schemes, pensions and insurances, it becomes increasingly important to understand the determinants of cognitive ability among ...
Doblhammer, Gabriele, Fritze, Thomas, van den Berg, Gerard J.   +2 more
core   +1 more source

Computer program for predicting off-design performance of centrifugal compressors [PDF]

, 1974
Complete knowledge of compressor overall geometry and working fluid total inlet conditions is required for program's use. On given speed line, compressor performance is calculated for range of inlet velocity levels.
Galvas, M. R.
core   +1 more source

TOMM20 as a driver of cancer aggressiveness via oxidative phosphorylation, maintenance of a reduced state, and resistance to apoptosis

Molecular Oncology, EarlyView.
TOMM20 increases cancer aggressiveness by maintaining a reduced state with increased NADH and NADPH levels, oxidative phosphorylation (OXPHOS), and apoptosis resistance while reducing reactive oxygen species (ROS) levels. Conversely, CRISPR‐Cas9 knockdown of TOMM20 alters these cancer‐aggressive traits.
Ranakul Islam, Megan E. Roche, Zhao Lin, Diana Whitaker‐Menezes, Victor Diaz‐Barros, Eurico Serrano, Maria Paula Martinez Cantarin, Nancy J. Philp, Atrayee Basu Mallick, Ubaldo Martinez‐Outschoorn   +9 more
wiley   +1 more source

Condições de trabalho do professor de Sociologia

Cadernos Cedes
O artigo tem como objetivo apresentar as condições de trabalho dos professores de Sociologia, no período atual, e, também, descrever e analisar as mudanças advindas de um conjunto de leis aprovadas no segundo semestre de 2009, no estado de São Paulo.
Ana Lúcia Lennert
doaj   +1 more source

Self-employed or not Self-employed? Working Conditions of ‘Economically Dependent Workers’ [PDF]

, 2013
In recent years, practices such as outsourcing and contracting-out have increasingly blurred the boundaries between dependent employment and self-employment.
Eurofound
core   +1 more source

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

Relationship between organizational commitment, working environment, and burnout in clinical nurses

Journal of Education and Health Promotion
BACKGROUND: Burnout is a mental condition caused by chronic emotional or psychological stress. Organizational commitment is always an important issue in the field of organizational development of clinical nurses. The study aimed to assess the association
Mona Alinejad-Naeini, Mahin Ghasemi, Mohammad Saeed Mirzaee, Farshad Heidari-Beni   +3 more
doaj   +1 more source

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan, Elizabeth Thomas, Mehari M. Weldemariam, Puranik Purushottamachar, Weiliang Huang, Maureen A. Kane, Yuji Zhang, Nicholas Ambulos, Bi‐Dar Wang, David Weber, Vincent C. O. Njar   +10 more
wiley   +1 more source