Results 261 to 270 of about 15,854,076 (410)

Unveiling unique protein and phosphorylation signatures in lung adenocarcinomas with and without ALK, EGFR, and KRAS genetic alterations

Molecular Oncology, EarlyView.
Proteomic and phosphoproteomic analyses were performed on lung adenocarcinoma (LUAD) tumors with EGFR, KRAS, or EML4–ALK alterations and wild‐type cases. Distinct protein expression and phosphorylation patterns were identified, especially in EGFR‐mutated tumors. Key altered pathways included vesicle transport and RNA splicing.
Fanni Bugyi, Mirjam Balbisi, Simon Sugár, Lóránd Váncza, Eszter Regős, Ilona Kovalszky, Ibolya Laczó, Tünde Harkó, Gábor Kecskeméti, Zoltán Szabó, Judit Moldvay, László Drahos, Lilla Turiák   +12 more
wiley   +1 more source

Working status among Dutch patients with rheumatoid arthritis: work disability and working conditions [PDF]

, 2004
Suzanne Verstappen, Annelies Boonen, J. W. J. Bijlsma, Erik Buskens, Harry Verkleij, Y Schenk, G A van Albada-Kuipers, D Hofman, J. W. G. Jacobson   +8 more
openalex   +1 more source

Joint contributions of psychological distress and demanding working conditions to short and long sickness absence among young and early midlife municipal employees. [PDF]

Eur J Public Health
Svärd AC, Kalima ML, Halonen JI, Mänty M, Kujanpää T, Roos E, Salmela J, Lallukka T.   +7 more
europepmc   +1 more source

Understanding and measuring mechanical signals in the tumor stroma

FEBS Open Bio, EarlyView.
This review discusses cancer‐associated fibroblast subtypes and their functions, particularly in relation to extracellular matrix production, as well as the development of 3D models to study tumor stroma mechanics in vitro. Several quantitative techniques to measure tissue mechanical properties are also described, to emphasize the diagnostic and ...
Fàtima de la Jara Ortiz, Chiara Cimmino, Maurizio Ventre, Alessandra Cambi   +3 more
wiley   +1 more source

Collective Bargaining for Educational Administrators: Oregon and Washington Principals' Perceptions of Working Conditions

, 2000
Patricia Boles
openalex   +2 more sources

Physicians as clinical directors: working conditions, psychosocial resources and self-rated health [PDF]

, 2004
Maud Lindholm, Elisabeth Dejin‐Karlsson, Jan Westin, Bo Hagström, Giggi Udén   +4 more
openalex   +1 more source

Creating Organisational Working Conditions Where Nurses Can Thrive: An International Action Research Study. [PDF]

Nurs Rep
Jacobs S, Moloney W, Terry D, Lewis PA, Topping A, González-Agüero M, Cavanagh S.   +6 more
europepmc   +1 more source

Beyond digital twins: the role of foundation models in enhancing the interpretability of multiomics modalities in precision medicine

FEBS Open Bio, EarlyView.
This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi, Xin Gao, Takashi Gojobori   +2 more
wiley   +1 more source

PVTE system performance improvement via numerical optimization of heat sink design and fluid working conditions. [PDF]

Sci Rep
Azirul A, Ibrahim A, Nazri NS, Jarimi H, Mohd Zainuri MAA, Syafiq U.   +5 more
europepmc   +1 more source

Possible role of human ribonuclease dicer in the regulation of R loops

FEBS Open Bio, EarlyView.
R loops play an important role in regulating key cellular processes such as replication, transcription, centromere stabilization, or control of telomere length. However, the unscheduled accumulation of R loops can cause many diseases, including cancer, and neurodegenerative or inflammatory disorders. Interestingly, accumulating data indicate a possible
Klaudia Wojcik, Paulina Krzeminska, Anna Kurzynska‐Kokorniak   +2 more
wiley   +1 more source