Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li +8 more
wiley +1 more source
"3E" Analysis and Working Fluid Selection for a Cogeneration System for Geothermal Large Temperature Difference Utilization. [PDF]
Yin J, Zhu B, Zhang Y, Huang J.
europepmc +1 more source
Engineered Lateral Roughness Element Implementation and Working Fluid Alteration to Intensify Hydrodynamic Cavitating Flows on a Chip for Energy Harvesting. [PDF]
Gevari MT +4 more
europepmc +1 more source
Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi +7 more
wiley +1 more source
Experimental Research on the Supply of Working Fluid for Fixed Diamond Wire Slicing Based on Ultrasonic Capillary Effect. [PDF]
Zhao J, Shen L, Zhang C, Wang Y.
europepmc +1 more source
Metal working fluid exposure and diseases in Switzerland. [PDF]
Koller MF +4 more
europepmc +1 more source
Evaluation of candidate working fluid formulations for the electrothermal - chemical wind tunnel [PDF]
Various candidate chemical formulations are evaluated as a precursor for the working fluid to be used in the electrothermal hypersonic test facility which was under study at the NASA LaRC Hypersonic Propulsion Branch, and the formulations which would ...
Akyurtlu, Ates, Akyurtlu, Jale F.
core +1 more source
Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada +5 more
wiley +1 more source
Study on the Spatial Damage Characteristics of Working Fluid in a Sandstone Reservoir and an Unplugged Fluid System. [PDF]
Xin X +6 more
europepmc +1 more source
Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey +12 more
wiley +1 more source

