Results 71 to 80 of about 2,005,023 (278)

Contribution of reactive and proactive control to children's working memory performance:Insight from item recall durations in response sequence planning [PDF]

open access: yes, 2014
The present study addressed whether developmental improvement in working memory span task performance relies upon a growing ability to proactively plan response sequences during childhood.
Chevalier, Nicolas   +4 more
core   +3 more sources

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

Working Memory, Rumination, and Autobiographical Memory Specificity Impairment [PDF]

open access: yesIranian Rehabilitation Journal, 2023
Objectives: Specificity impairment is a memory alteration that occurs in people with major depressive disorder (MDD). In this investigation, we intended to shine a light on obscure aspects of executive resource and capture and rumination frameworks to ...
Pouria Rahgosha   +3 more
doaj  

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

open access: yesMolecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute   +4 more
wiley   +1 more source

Shape and spatial working memory capacities are mostly independent

open access: yesFrontiers in Psychology, 2015
Whether visual working memory consists of a common storage resource or of multiple subsystems has been a controversial issue. Logie (1995) suggested that it can be divided into visual (for color, shape, objects, etc.) and spatial working memory (for ...
Motoyuki eSanada   +3 more
doaj   +1 more source

Math Anxiety and Working Memory Updating: Difficulties in Retrieving Numerical Information From Working Memory

open access: yesFrontiers in Psychology, 2020
This study aimed to determine whether math anxiety was related to working memory (WM) updating performance and, specifically, to the retrieval and substitution components of updating.
Santiago Pelegrina   +3 more
doaj   +1 more source

Synergies between processing and memory in children's reading span. [PDF]

open access: yes, 2010
Previous research has established the relevance of working memory for cognitive development. Yet the factors responsible for shaping performance in the complex span tasks used to assess working memory capacity are not fully understood.
Harvey, Katarina   +3 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Simple and Complex Working Memory Tasks Allow Similar Benefits of Information Compression

open access: yesJournal of Cognition, 2018
Complex working memory span tasks were designed to engage multiple aspects of working memory and impose interleaved processing demands that limit the use of mnemonic strategies, such as chunking.
Fabien Mathy   +2 more
doaj   +1 more source

The role of lipid metabolism in neuronal senescence

open access: yesFEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari   +2 more
wiley   +1 more source

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