Results 51 to 60 of about 125,002 (259)

Binding Costs in Processing Efficiency as Determinants of Cognitive Ability

open access: yesJournal of Intelligence, 2021
Performance in elementary cognitive tasks is moderately correlated with fluid intelligence and working memory capacity. These correlations are higher for more complex tasks, presumably due to increased demands on working memory capacity.
Benjamin Goecke   +2 more
doaj   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

open access: yesMolecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute   +4 more
wiley   +1 more source

The Role of Auditory and Visual Working Memory Capacity in Metasyntactic Abilities

open access: yesدراسات: العلوم التربوية, 2021
The present study aims to explore the role of auditory and visual working memory capacity in metasyntactic abilities, among a sample of 134 undergraduate students from the scientific and humanity colleges in Yarmouk University.
Raneem Abumousa, Firas Alhamouri
doaj  

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Visual working memory capacity does not modulate the feature-based information filtering in visual working memory.

open access: yesPLoS ONE, 2011
BackgroundThe limited capacity of visual working memory (VWM) requires us to select the task relevant information and filter out the irrelevant information efficiently.
Jifan Zhou   +5 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

open access: yesMolecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis   +3 more
wiley   +1 more source

A Positive Association between Working Memory Capacity and Human Creativity: A Meta-Analytic Evidence

open access: yesJournal of Intelligence, 2023
Creativity serves as a fountain for social and scientific development. As one of the most crucial human capabilities, creativity has been believed to be supported by the core component of higher cognitive functions—working memory capacity (WMC). However,
Zheng Gong   +5 more
doaj   +1 more source

Working memory capacity and the scope and control of attention [PDF]

open access: yesAttention, Perception, & Psychophysics, 2015
Complex span and visual arrays are two common measures of working memory capacity that are respectively treated as measures of attention control and storage capacity. A recent analysis of these tasks concluded that (1) complex span performance has a relatively stronger relationship to fluid intelligence and (2) this is due to the requirement that ...
Zach, Shipstead   +2 more
openaire   +2 more sources

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

open access: yesMolecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu   +13 more
wiley   +1 more source

Measures of working memory capacity and l2 oral fluency Measures of working memory capacity and l2 oral fluency

open access: yesIlha do Desterro, 2008
A considerable amount of research is now available which addresses the nature of nonnative oral fluency. The research carried out over the past two decades has shown with some consistency that (1)nonnative speech production tends to reproduce first ...
Mailce Borges Mota Fortkamp
doaj  

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