Results 111 to 120 of about 12,358,779 (298)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

LIVING THE SUFFERING AND CHALLENGES IN THE WORK: SELF-CRITICAL OPINIONS OF A NURSE-EDUCATORS GROUP [PDF]

Revista Eletrônica de Enfermagem, 2004
This is a cutting of my máster, thisI had as objective to know the nurses-educators self-criticalexpressions concerning the working process on professional teaching for technical nursing.
Marta Lenise do Prado, Claudiniete Maria da Conceição Bezerra Vasconcelos   +1 more
doaj  

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Research of the vacuum brake booster working process

Қарағанды университетінің хабаршысы. Физика сериясы
The creation of a laboratory installation was carried out with an aim to ensure the study of the working processes and characteristics of vacuum boosters as a part of hydraulic brake drives for vehicles with a gross weight of up to 3.5 tons for civilian
Н. Скляров, А. Шаповалов, П. Черненко, А. Корнев, A. Кашканов, В. Кашканов, В. Кучерук   +6 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Working Papers, Working Atlas

, 2011
Le carnet des Working Papers et Working Atlas de l'IFG a pour objet de diffuser des recherches novatrices de doctorants, docteurs, ou chercheurs associés à notre laboratoire.
Kevin Limonier
core  

Export learning process in local supplier networks [PDF]

, 2004
The objective of this study is to analyze the influence of a multinational corporation on the productive network of the host territory and the proliferation of entrepreneurs.
Cerviño, Julio, Cubillo Pinilla, José María   +1 more
core  

Good Corporate Governance and Working Conditions at Petrol Stations: A Critical Political Economy Perspective

JSP: Jurnal Ilmu Sosial dan Ilmu Politik
This study examines the claim that the benefits of good corporate governance (GCG) extend to all stakeholders, with a specific focus on the advantages for workers during operational processes.
Ardiyansyah Ardiyansyah
doaj   +1 more source