Results 111 to 120 of about 15,281,206 (293)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Research of the vacuum brake booster working process

Қарағанды университетінің хабаршысы. Физика сериясы
The creation of a laboratory installation was carried out with an aim to ensure the study of the working processes and characteristics of vacuum boosters as a part of hydraulic brake drives for vehicles with a gross weight of up to 3.5 tons for civilian
Н. Скляров, А. Шаповалов, П. Черненко, А. Корнев, A. Кашканов, В. Кашканов, В. Кучерук   +6 more
doaj   +1 more source

LIVING THE SUFFERING AND CHALLENGES IN THE WORK: SELF-CRITICAL OPINIONS OF A NURSE-EDUCATORS GROUP [PDF]

Revista Eletrônica de Enfermagem, 2004
This is a cutting of my máster, thisI had as objective to know the nurses-educators self-criticalexpressions concerning the working process on professional teaching for technical nursing.
Marta Lenise do Prado, Claudiniete Maria da Conceição Bezerra Vasconcelos   +1 more
doaj  

European Symposium on Computer Aided Process Engineering--13 : 36th European symposium of the Working Party on Computer Aided Process Engineering : ESCAPE-13, 1-4 June, 2003, Lappeenranta, Finland /

, 2003
This book contains papers presented at the 13th European Symposium on Computer Aided Process Engineering (ESCAPE-13). The ESCAPE symposia bring together scientists, students and engineers from academia and industry, who are active in the research and ...
European Federation of Chemical Engineering.Working Party on Computer Aided Process Engineering., European Symposium on Computer Aided Process Engineering(13th :2003 :Lappeenranta, Finland), Turunen, Ilkka., Kraslawski, Andrzej.   +3 more
core  

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Good Corporate Governance and Working Conditions at Petrol Stations: A Critical Political Economy Perspective

JSP: Jurnal Ilmu Sosial dan Ilmu Politik
This study examines the claim that the benefits of good corporate governance (GCG) extend to all stakeholders, with a specific focus on the advantages for workers during operational processes.
Ardiyansyah Ardiyansyah
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source