Results 111 to 120 of about 6,947,028 (305)

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

Modeling of Boring Mandrel Working Process with Vibration Damper. [PDF]

open access: yesMaterials (Basel), 2020
Sentyakov K   +4 more
europepmc   +1 more source

Burglary project [PDF]

open access: yes, 2010
This report outlines the process and findings from an innovative project for students. This work was part of the curriculum and involved students working with West Yorkshire Police as part of the safer Leeds project in designing and making a film for ...
Kenyon, AJ   +3 more
core  

[Work-in-process] + [work-in-progress]

open access: yesAusArt, 2020
En esta aportación pretendo acercarme a un supuesto escenario cubano como posibilidad divagante entre cierto espacio vivido y espacio construido. Este acercamiento se iniciará a través del bozal, contrariedad identificativa del medio de comunicación que los esclavos africanos desarrollaron en la isla, distinguiéndose en ella la no sistematicidad de ...
openaire   +3 more sources

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

open access: yesFEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva   +10 more
wiley   +1 more source

Inscriptions: drawing, making, thinking [PDF]

open access: yes, 2010
‘Inscription: drawing, making, thinking’ brought together the work of David Conneam, Philip Eglin and Charlotte Hodes, it included drawings, ceramics, moving image and evidence of their working process.
Hodes, Charlotte
core  

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Career entry and development profile companion guide: a guide for ITT tutors and induction tutors [PDF]

open access: yes, 2011
Who is the companion guide for? This guide is for initial teacher training (ITT) tutors working with trainees/teachers, and for induction tutors in schools working with newly qualified teachers (NQTs) during their induction period.

core  

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

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