In-Line UV-Vis Spectroscopy as a Fast-Working Process Analytical Technology (PAT) during Early Phase Product Development Using Hot Melt Extrusion (HME). [PDF]
Pharmaceutics, 2018 Schlindwein W +5 more
europepmc +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Experimental characterization of single screw expander performance under different testing conditions and working fluids [PDF]
, 2015 During the last years, one of the most popular ways to recover low-grade waste heat is the organic Rankine cycle (ORC). This technology is widely studied and continuously optimized and, as a result, there are many efficient installations available on the
Gusev, Sergei +2 more
core +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
THE WORKING PROCESS RESEARCH OF COMPACT FOUR-STROKE PETROL INTERNAL COMBUSTION ENGINE PROCESS
RUDN Journal of Engineering Research, 2015 The reasons of choice, advantages and description of compact stand for receiving four-stroke engine characteristics and all of the components are adduced in the article.
S V Gusakov, M V Azanov, A A Savastenko
doaj
Memo on the Impact of the United Kingdom\u27s Flexible Working Act [PDF]
, 2008 Since taking effect in 2003, the United Kingdom’s Flexible Working Act has granted parents with children under the age of 6, or with disabled children under the age of 18, the right to request flexible working arrangements from their employers if they ...
Boots, Shelley Waters, Danziger, Anna
core +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
The Deadlock that never Happened: the Impact of Enlargement on the Common Foreign and Security Policy Council Working Groups [PDF]
Contrary to some previous assumptions, the enlargement did not halt the Common Foreign and Security Policy (CFSP) decision-making process in a substantial way.
Ana E. Juncos, Karolina Pomorska
core