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Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
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Research and application of pre-excavated double withdrawal channel technology without coal pillar abandonment. [PDF]
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Patient and public involvement in health and social care doctoral research: recommendations co-produced by doctoral researchers, public contributors, and a public involvement coordinator. [PDF]
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Topology optimization design of excavator working device based on equivalent static loads. [PDF]
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Nurses' sleep quality and medication administration errors: A cross-sectional study based on the ten rights framework. [PDF]
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