Results 201 to 210 of about 6,947,028 (305)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Building a Sexual and Reproductive Health Module for Implementation in Early Psychosis Programs: A Co-creation Process: Création d'un module sur la santé sexuelle et reproductive à mettre en œuvre dans les programmes d'intervention précoce en cas de psychose : un processus de création conjointe. [PDF]

Can J Psychiatry
Barker LC, Zaheer J, Wong-Lee R, Kearney H, Ampofo A, Bodogh V, Dobinson C, Dmytryshyn R, Dunn S, Foussias G, Kozloff N, Lam JSH, Rodriguez A, Sirotich F, Soklaridis S, Villanueva V, Voineskos AN, Vigod SN.   +17 more
europepmc   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Study on crack propagation law of overlying strata in the process of small coal pillar mining in inclined extra-thick coal seam. [PDF]

Sci Rep
Lu W, Zhao P, Jin Q, Jin H, Li S, Bai J.
europepmc   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Use of AI within COA linguistic validation and eCOA migration processes: analysis and good practice recommendations. [PDF]

J Patient Rep Outcomes
McKown S, Arnold B, Boucher F, Correia H, Eremenco S, Geršić T, Johnson M, Koumbarou A, Matias I, Parks-Vernizzi E, Poepsel T, Son J, Strouse E, Terwee CB, Wade M.   +14 more
europepmc   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Exploring how patient involvement is enacted in the Swedish national system for knowledge-driven management - "work as imagined and work as done". [PDF]

BMC Health Serv Res
Petersson C, Määttä S, Gäre BA, Henriks G, Ånfors H, Nilsagård Y.   +5 more
europepmc   +1 more source

Work process

, 2009
Vondeling, Hindrik, Tufanaru, C., Atanasijevic, D., Meiesaar, K.   +3 more
openaire   +1 more source