Results 211 to 220 of about 409,228 (301)

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw, Karishma Randhave, Ekta Anand, Ziang (Debbie) Song, Wangzhen Shen, Jing‐Qiong Kang   +5 more
wiley   +1 more source

Distribution and Effects of Model Palladium-Doped Nanoplastics in the Marine Mussel <i>Mytilus galloprovincialis</i>. [PDF]

Nanomaterials (Basel)
González-Soto N, Schirinzi GF, Bucher G, Bilbao E, Orbea A, Mehn D, Gilliland D, Serra MÁ, Mitrano DM, Passos MSP, Cajaraville MP.   +10 more
europepmc   +1 more source

Plasma EV Proteomics Identifies ECM Remodeling and Inflammatory Proteins LUM and C7 as Candidate Biomarkers in FSHD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral muscular dystrophy (FSHD) is one of the most debilitating and common muscular dystrophies. Despite its severity, no approved therapy exists for FSHD patients. However, several therapeutic candidates are currently under development, and some have recently entered clinical trials, marking the need for reliable ...
Mustafa Bilal Bayazit, Chiranth K. Nagaraj, Jackson S. Newell, Kim Truc Nguyen, Xilal Y. Rima, Jacob Doon‐Ralls, Eduardo Reátegui, Jeffrey M. Statland, Rabi Tawil, Kevin M. Flanigan, Scott Q. Harper, Nizar Y. Saad   +11 more
wiley   +1 more source

Asmeret Asefaw Berhe. [PDF]

New Phytol
europepmc   +1 more source

The efectiveness of perioperative abdominal wall exercises upon functional recovery and return to work after Lichtenstein tension - free repair: a prospective randomized case -control study. [PDF]

Hernia
Trisca R, Oprea V, Toma M, Cadar I, Bucuri CE, Finascu F, Andercou O, Bodog F, Matei IR, Siserman C, Chiroban O, Gherman C.   +11 more
europepmc   +1 more source

Onasemnogene Abeparvovec in Patients With SMA: Interim Results of the RESTORE Registry in Japan

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective There are limited real‐world data regarding the safety and effectiveness of onasemnogene abeparvovec (OA; Zolgensma) infusion, a one‐time gene replacement therapy, for Japanese patients with spinal muscular atrophy (SMA). We aimed to improve understanding of the real‐world outcomes for OA in Japan.
Kayoko Saito, Kamal Benguerba, Ken Tsuchida, Kazushige Yazawa, Isao Tsumiyama, Hiromitsu Kayama, Sandra P. Reyna, Farid Khan, Richard S. Finkel   +8 more
wiley   +1 more source

The Last Days Of Women\u27s Cinema

, 2006
White, Patricia
core   +1 more source

Simple Electroporation of <i>Chlamydomonas reinhardtii</i> Strains With an Intact Cell Wall. [PDF]

Bio Protoc
Meßmer M, de Carpentier F, Lam E, Hong M, Wakao S, Schroda M, Niyogi KK.   +6 more
europepmc   +1 more source

A Two‐Stage Questionnaire and Actigraphy Screening for iRBD in a Multicenter Retrospective Cohort

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Isolated rapid‐eye‐movement sleep behavior disorder is a prodromal marker of synucleinopathies. However, most cases remain undiagnosed due to the insufficient predictive value of questionnaires and limited access to confirmatory video‐polysomnography. We assessed a two‐stage screening strategy combining a brief questionnaire on rapid‐
Caleb A. Massimi, Giorgio Ricciardiello Mejia, Andre Metzger, Kang Hyun Ryu, Salonee Marwaha, Eva Grzegorczyk, Li Zhou, Eliana Jacobs, Boris Gilyadov, Claudia Kunney, Liqhwa Ncube, Ankit Parekh, Emmanuel Mignot, Fanny M. Elahi, Joseph Winer, Kathleen Poston, Andreas Brink‐Kjaer, Emmanuel H. During   +17 more
wiley   +1 more source

First-Trimester Bleeding and the Risk of Pregnancy Loss in a Prospective Cohort. [PDF]

Obstet Gynecol
Sundermann AC, Jasper EA, Chumakov PE, Kumar SE, Hartmann KE, Velez Edwards DR.   +5 more
europepmc   +1 more source