Results 141 to 150 of about 2,414,153 (293)
Advanced Science, EarlyView.Using iPSC‐derived motoneurons and postmortem tissue from FUS‐ALS patients, it is demonstrated that increased mitochondrial transcription leads to elevated cytosolic double‐stranded RNA (dsRNA) levels. This aberrant accumulation activates a RIG‐I–dependent innate immune response leading to neurodegeneration, which is amenable for FDA‐ and EMA‐approved ...
Marcel Naumann +26 more
wiley +1 more source
For the children? A mixed methods analysis of World Bank structural adjustment loans, health projects, and infant mortality in Latin America. [PDF]
Global Health, 2021 Noy S.
europepmc +1 more source
Advanced Science, EarlyView.This study reports that SBNO1 protein is upregulated in several cancer entities. SBNO1 protein interacts with the basal transcription factor TFIID via TAF4, enabling its recruitment to transcription start sites and the modulation of target gene expression.
Sarah Fritzsche +21 more
wiley +1 more source
Identifying Nontraditional Epidemic Disease Risk Factors Associated with Major Health Events from World Health Organization and World Bank Open Data. [PDF]
Am J Trop Med Hyg, 2021 Lugo-Robles R +3 more
europepmc +1 more source
Advanced Science, EarlyView.Cancer cell‐intrinsic cholesterol promotes the S‐palmitoylation of SP1, increasing its nuclear translocation and driving the transcription and secretion of MDK, which in turn facilitates the differentiation of macrophages into a lipid‐associated phenotype.
Shirong Peng +12 more
wiley +1 more source
5 Years in Juntos: New Evidence on the Program’s Short and Long-Term Impacts
Economía, 2012 This study presents results from a quantitative impact evaluation of the Conditional Cash Transfer (CCT) program, Juntos, in Peru. Using instrumental variable techniques, it estimates the overall impact of Juntos five years after its initial rollout and ...
Elizaveta Perova, Renos Vakis
doaj
Generalized Mechanism Model for Ecosystem Hysteresis
Advanced Science, EarlyView.A simplified model examines ecosystem transitions into alternative states after disturbances by leveraging positive and negative feedbacks. It identifies critical tipping points and quantifies hysteresis. Tests conducted on lakes, grasslands, and pitcher‐plant leaves align closely with empirical data and enable the prediction of recovery trajectories ...
Yanbin Hao +9 more
wiley +1 more source
Regional anesthesia educational material utilization varies by World Bank income category: A mobile health application data study. [PDF]
PLoS One, 2021 Moll V +4 more
europepmc +1 more source
Advanced Science, EarlyView.A (2R,3R)‐butanediol dehydrogenase from Bacillus subtilis (BsBDH) is engineered for the enantioselective synthesis of 2‐hydroxycyclohexanone. A PASS computational design strategy is proposed to enhance the thermostability of BsBDH. Moreover, ESM‐1v combined with ISM is utilized for enhancing and inverting its stereoselectivity.
Haote Ding +5 more
wiley +1 more source