Results 41 to 50 of about 192,742 (261)

Financing networks of care: a cross-case analysis from six countries

open access: yesBMJ Open, 2023
Objectives Describe experiences of countries with networks of care’s (NOCs’) financial arrangements, identifying elements, strategies and patterns.Design Descriptive using a modified cross-case analysis, focusing on each network’s financing functions ...
Sanam Roder-DeWan   +2 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

open access: yesFEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang   +4 more
wiley   +1 more source

What Are Governments Spending on Health in East and Southern Africa?

open access: yesHealth Systems & Reform, 2018
Progress toward universal health care (UHC) in Africa will require sustained increases in public spending on health and reduced reliance on out-of-pocket financing.
Moritz Piatti-Fünfkirchen   +2 more
doaj   +1 more source

The world bank at the Millennium*

open access: yesThe Economic Journal, 1999
This article focuses on the World Bank's role in the global economy of the 21st century. Today, the World Bank's core mission remains the promotion of economic growth and the eradication of poverty in the less developed countries. The instruments used to pursue that objective have changed over the years, to be sure. Over the Bank's history, the balance
openaire   +2 more sources

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

A multisectoral institutional arrangements approach to integrating civil registration, vital statistics, and identity management systems

open access: yesJournal of Health, Population and Nutrition, 2019
This paper reviews the essential components of a recommended institutional arrangements framework of integrated civil registration and vital statistics (CRVS) and civil identification systems.
Samuel Mills   +2 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

open access: yesMolecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi   +11 more
wiley   +1 more source

Reducing child mortality in India in the new millennium

open access: yesBulletin of the World Health Organization, 2000
Globally, child mortality rates have been halved over the last few decades, a developmental success story. Nevertheless, progress has been uneven and in recent years mortality rates have increased in some countries.
Mariam Claeson   +3 more
doaj  

Modelling the economic burden of SARS-CoV-2 infection in health care workers in four countries

open access: yesNature Communications, 2023
Health care workers (HCWs) experienced greater risk of SARS-CoV-2 infection during the COVID-19 pandemic. This study applies a cost-of-illness (COI) approach to model the economic burden associated with SARS-CoV-2 infections among HCWs in five low- and ...
Huihui Wang   +14 more
doaj   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

open access: yesFEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill   +4 more
wiley   +1 more source

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