Results 71 to 80 of about 6,788,343 (336)

World Bank East Asia and Pacific Economic Update 2010, Volume 1 : Emerging Stronger from the Crisis

, 2010
East Asia has recovered from the economic and financial crisis. Largely thanks to China, the region's output, exports and employment have mostly returned to the levels before the crisis. Leading the global
World Bank
core   +1 more source

FY 2023 Albania Country Opinion Survey – Pulse Report

, 2023
The Country Opinion Survey in Albania assists the World Bank Group (WBG) in better understanding how stakeholders in Albania perceive the WBG. It provides the WBG with systematic feedback from national and local
World Bank
core   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Reducing child mortality in India in the new millennium

Bulletin of the World Health Organization, 2000
Globally, child mortality rates have been halved over the last few decades, a developmental success story. Nevertheless, progress has been uneven and in recent years mortality rates have increased in some countries.
Mariam Claeson, Eduard R. Bos, Tazim Mawji, Indra Pathmanathan   +3 more
doaj  

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Investing in children's health: what are the economic benefits?

Bulletin of the World Health Organization
This paper argues that investing in children's health is a sound economic decision for governments to take, even if the moral justifications for such programmes are not considered.
Paolo C. Belli, Flavia Bustreo, Alexander Preker   +2 more
doaj   +1 more source

Invitations and incentives: a qualitative study of behavioral nudges for primary care screenings in Armenia

BMC Health Services Research, 2020
Background Non-communicable diseases account for a growing proportion of deaths in Armenia, which require early detection to achieve disease control and prevent complications.
Estelle Gong, Adanna Chukwuma, Emma Ghazaryan, Damien de Walque   +3 more
doaj   +1 more source

The World Bank Country Survey FY 2012

, 2012
The Country Survey for FY2012 in Afghanistan assists the World Bank in gaining a better understanding of how stakeholders in Afghanistan perceive the Bank. It provides the Bank with systematic feedback from
World Bank Group
core   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Evaluating the effectiveness of incentives to improve HIV prevention outcomes for young females in Eswatini: Sitakhela Likusasa impact evaluation protocol and baseline results

BMC Public Health, 2020
Background Eswatini continues to have the highest prevalence of HIV in the world, and one of the highest HIV incidences among adult populations (aged 15–49). This analysis reports on both key elements of study design/protocol and baseline results from an
Marelize Gorgens, Andrew F. Longosz, Sosthenes Ketende, Muziwethu Nkambule, Tengetile Dlamini, Mbuso Mabuza, Kelvin Sikwibele, Vimbai Tsododo, Mthokozisi Dlamini, Futhie Dennis-Langa, Wendy Heard, Andrea Low, Pandu Harimurti, David Wilson, Khanya Mabuza, Damien de Walque   +15 more
doaj   +1 more source