Results 91 to 100 of about 177,830 (306)
Revue des Mondes Musulmans et de la Méditerranée, 2017 The globalisation of the art world, while expanding the horizons of Western actors and observers towards new territories, focuses their attention on restricted times and spaces.
Ilker Birkan, Jérémie Molho
doaj +1 more source
A Case Study of an Online Science Fair- The International Cyberscience Expo 2000 (ICE2000) [PDF]
, 2000 The International CyberScience Expo 2000 is a project that promotes project-based, science learning by secondary students. The event was organized and held entirely online in a collaborative virtual learning environment called ScienceMOO.
Murfin, B.
core +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
The Changing Fortunes of Fairs in Medieval and Early Modern Europe: Warfare, Transaction Costs, and the 'New Institutional Economics' [PDF]
This paper revisits, modifies, and combines elements of three major 'institutional' international-trade models, none of which has yet fully received the attention that it deserves, to provide a new explanation for the growth, decline, and then rebirth of
John H. Munro
core
High-end fashion manufacturing in the UK - product, process and vision: Recommendations for a Designer and Fashion Manufacturer Alliance and a Designer Innovation and Sampling Centre [PDF]
, 2008 The Centre for Fashion Enterprise (CFE) was commissioned by the Department of Culture, Media and Sport (DCMS) to undertake a feasibility study to explore fully the market need for a new high-end production hub.
Karra, Neri, Malem, Wendy, Miller, Jan
core
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source