Results 121 to 130 of about 177,830 (306)

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

FEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi, Zainab Quraishi, Shima Khezri Azizi Far, Madaleine Ward, Aidan Conway, Reem Abdulredha, Eman Mshari, Yousif A. Shamsaldeen   +7 more
wiley   +1 more source

Building Global Knowledge Pipelines The Role of Temporary Clusters [PDF]

Business people and professionals come together regularly at trade fairs, exhibitions, conventions, congresses, and conferences. Here, their latest and most advanced findings, inventions and products are on display to be evaluated by customers and ...
Anders Malmberg, Harald Bathelt, Peter Maskell   +2 more
core  

Norms and Law: Putting the Horse Before the Cart [PDF]

, 2012
Law and society scholars have long been fascinated with the interplay of formal legal and informal extralegal procedures. Unfortunately, the fascination has been accompanied by imprecision, and scholars have conceptually conflated two very different ...
Richman, Barak D.
core   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Strategic Behaviour in the International Exploitation of TV Formats - A Case Study of the Idols Format [PDF]

The international trade in TV formats has been increasing steadily. According to the Format Recognition and Protection Association (a format producers' industry association) the value of the global TV format business exceeds € 9.3 billion (FRAPA 2009 ...
Kretschmer, Martin, Singh, Sukhpreet
core  

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Making history, making place—contextualising the built heritage of world expos 2010 and 2015

Built Heritage
Be it the 1873 World’s Fair in Vienna, which established the city's status as a link between the Occident and Orient, or the very first Great Exhibition in 1851 in London, which showcased the then British empire to a global public and the world to its ...
Pascal Honisch
doaj   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Les visées politiques et identitaires de l’orientalisme architectural au miroir d’une anthologie des pavillons de la Tunisie dans les expositions universelles (1876-2010)

Diacronie. Studi di Storia Contemporanea, 2014
This article conveys an historical analysis on some pavilions representing the Tunisian presence in world fairs from 1851 to 2010. It focuses particularly on their architectural components.
Nader Meddeb est architecte diplômé en 2005 de l’École Nationale d’architecture et d’Urbanisme de Sidi Bou Saïd à Tunis. Il finalise actuellement un Ph.D en aménagement à l’Université de Montréal. Auteur de plusieurs articles, sections de livres et de communications libres, il s’intéresse au rapport de l’architecture de la ville à certaines notions comme l’espace public, la biopolitique, la gouvernance, le pouvoir, l’architecture des régimes totalitaires.
doaj