Results 121 to 130 of about 5,929,395 (302)
HISTORICAL CURRENT OPINION ON THE ROLE OF HISTORIAN IN SOCIETY: UKRAINIAN DISCOURSE
Київські історичні студії, 2019 The works of Ukrainian historians of 1990s — early 21 century are analysed in the article. The status of historian in the modern society is clarified by the author. Historian’s new functions are pointed out in the research, the challenges that scientists
Galyna Sagan
doaj +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
The Role of Religious Traditions in the Development of Turkic Culture and their Importance for Contemporary Society [PDF]
Pharos Journal of TheologyThe purpose of the study is to examine the role of religious traditions in shaping Turkic culture and their importance for contemporary Kazakhstani society.
Fariza Bekenova +5 more
doaj +1 more source
Context for Confusion: Understanding Babel in the Book of Beginnings [PDF]
, 2018 The meaning of the Tower of Babel episode in Genesis 11 proves to be continually elusive for both biblical scholars and pastors. While the results of this momentous event in world history seem obvious, owing to the racial and linguistic diversity present
Osselaer, Douglas R
core +1 more source
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
Intervento sulla World History [PDF]
, 2015 Riflessioni sugli apporti scientifici della World History e sulle sue prospettive di diffusione nella storiografia ...
MERIGGI, MARCO
core
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
The First World War Letters of H.J.C. Peirs: A Digital History
, 2019 This poster provides a high-level overview of The First World War Letters of H.J.C. Peirs: A Digital History project, giving information on its creation, the collection of letters, how it has used digital mapping, and its use in the ...
Isherwood, Ian A. +2 more
core
Molecular Oncology, EarlyView.The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués +3 more
wiley +1 more source
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source