Results 141 to 150 of about 5,929,395 (302)
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Editorial Introduction: The utility and futility of 'the nation' in histories of Aotearoa New Zealand. [PDF]
, 2011 An introduction is presented which discusses articles in the issue on New Zealand history, including one on interracial rape and sexual violence in the 1860s, one on postcolonial methodology and the historical concept of the British World, and one on ...
Byrnes, Giselle, Coleborne, Catharine
core +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Book review: the power of ideology: from the Roman Empire to Al-Qaeda [PDF]
, 2012 Since the Roman Empire, leaders have used ideology to organize the masses and instil amongst them a common consciousness, and equally to conquer, assimilate, or repel alternative ideologies.
Papagaryfallou, Ioannis
core
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
World history and world outlook [PDF]
, 2012 La historia mundial es una forma particularmente adecuada para hacer frente al etnocentrismo. Los textos sobre historia general existentes hasta la fecha mencionan a China en uno o dos capítulos, mientras que dedican el resto de su tiempo a Europa.
Hodgson, Marshall G. S.
core +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
[Review of] John Higham (Ed.), Ethnic Leadership in America [PDF]
, 1979 The growing awareness of America\u27s ethnic pluralism has become one of the factors shaping modern American history. Ethnic writers, as well as ethnic leaders, began the task of illuminating the meaning of their own historic and cultural traditions ...
Blicksilver, Edith
core +1 more source