Results 41 to 50 of about 27,130 (265)

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

open access: yesFEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel   +4 more
wiley   +1 more source

Why human connection is the true metric of research success

open access: yesFEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan   +3 more
wiley   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

open access: yesFEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero   +5 more
wiley   +1 more source

The Analysis of 10 Foods with Borrowed Names in English Language

open access: yes, 2023
There is no language in the world which does not have at least one borrowed words in its vocabulary. Any language has 20 or 30 percent borrowed words.
Xusanboy o’g’li, Sufiyev Hakimjon
core   +1 more source

Artificial Intelligence and Mental Well‐Being in Adult Education: Implications for Practice and Professional Responsibility

open access: yesNew Directions for Adult and Continuing Education, EarlyView.
ABSTRACT Mental well‐being is central to adult learner success, yet many adult education institutions lack capacity to provide timely and accessible support. This article examines how artificial intelligence (AI) can strengthen mental health–adjacent supports in adult and continuing higher education, with attention to professional practice and ...
Adam L. McClain, Thomas Wade
wiley   +1 more source

“OGNI PERSONA È LINGUISTICAMENTE UNA CITTÀ DI MARE”: FRA LINGUE, VITA E NARRAZIONE: LE AUTOBIOGRAFIE LINGUISTICHE DEI DOCENTI”

open access: yesItaliano LinguaDue, 2021
Oltre venti autobiografie linguistiche elaborate, senza indicazioni vincolanti, da operatori e insegnanti italiani dei tre ordini scolastici sono esaminate, oltre che in relazione a tempi e modalità della scrittura, nei loro contenuti salienti, che ...
Cristina Fraccaro, Antonella Strazzari
doaj   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi   +2 more
wiley   +1 more source

Methods of teaching a foreign language

open access: yes, 2023
Teaching foreign languages occupies a significant place in the modern world; new social trends have led to the fact that languages are necessary not only for travel, but for study and work. The main goal of teaching a foreign language is the formation of
Nazarova Gulnara Usman kizi
core   +1 more source

A Qualitative Analysis of Patient Perspectives and Preferences in Lupus Management to Guide Lupus Guidelines Development

open access: yesArthritis Care &Research, EarlyView.
Objective A patient‐centered approach for chronic disease management, including systemic lupus erythematosus (SLE), aligns treatment with patients’ values and preferences, leading to improved outcomes. This paper summarizes how patient experiences, perspectives, and priorities informed the American College of Rheumatology (ACR) 2024 Lupus Nephritis (LN)
Shivani Garg   +20 more
wiley   +1 more source

Finding their Voices: The Young-Adult Poets of the Urdd National Eisteddfod

open access: yesInternational Journal of Young Adult Literature
Very little scholarly research has been undertaken on literary competitions for children and young people despite their potential in shaping and developing young writers, a process which is especially important in ensuring the vitality of minority ...
Hannah Sams
doaj   +1 more source

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