Results 231 to 240 of about 141,531 (307)

Assessing the role(s) of human touch in immersive entertainment. [PDF]

Iperception
Gao Y, Spence C.
europepmc   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Emotional Design in Chinese Pictographic Character Learning: Effects on Cognitive Load, Aesthetic Pleasure, and Intrinsic Motivation Among CSL Learners. [PDF]

Behav Sci (Basel)
Liu B, Wang J, Yue Z, Ma J, Zhang J.
europepmc   +1 more source

Decreased cold‐sensing function of the transient receptor potential channel TRPM8 from tailed amphibians

FEBS Open Bio, EarlyView.
Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao, Daiki Kobayashi, Shogo Hori, Osamu Saitoh   +3 more
wiley   +1 more source

Revisiting the enigmatic Cheirolepidiaceae: origins, phylogenetic relationships, and a new whole-plant concept. [PDF]

Ann Bot
Andruchow-Colombo A, Matsunaga KKS.
europepmc   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

First new species of the Neotropical genus <i>Lactistomyia</i> Melander, 1902 (Diptera, Hybotidae) from the Palearctic Region. [PDF]

Zookeys
Jung S, Kim S, Shin S.
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Building Expression into Virtual Characters

Steed, A., Tanguy, E., Slater, M., Loscos, C., Vinayagamoorthy, Vinoba, Pan, Xueni, Gillies, Marco   +6 more
core  

Character style and relational judgments in human-AI romance: trust, commitment, intimacy, and passion. [PDF]

Front Psychol
Niu J, She W, Cheng W, Dou X, Jia X.
europepmc   +1 more source