Results 31 to 40 of about 55,148 (257)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

INNOVATION AND WORLD POLITICS

Сравнительная политика, 2015
Education and science becomethe key realms of innovational reforms in theeconomic, legal and political arenas. Thekey to success in formulating national policyin the sphere of education and science liesin the professional combination of the generallaws ...
Alexei D. Voskressenski
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

The politics of world politics

, 2015
Foreword, 5 I Raimo Väyrynen: Thorstein Veblen’s Social Theory of War, 9 Jyrki Käkönen: Global Power Transition: From Trans-Atlantic to Asia-Pacific Centred Order, 36 Mika Aaltola: The Sagas of the Volcanic Ash: Narrating Europe’s slipping position through airtravel shocks, 65 Heino Nyyssönen: The World according to Emmanuel Goldstein: George ...
Palonen, Kari, Björk, Anna, Korvela, Paul-Erik   +3 more
openaire   +3 more sources

Potential for Using Artifical Intelligence in Public Administration

ECONOMICS
Artificial intelligence has become a defining technology for the last decade and possibly the next few. Every day, new and new applications are created based on large language models (LLM), a little hastily called artificial intelligence (AI).
Borissov Borislav, Hristozov Yanko
doaj   +1 more source

Private sector quality interventions to improve maternal and newborn health in low- and middle-income countries: a scoping review

Frontiers in Public Health
IntroductionThe private health sector provides significant maternal and newborn health (MNH) services in mixed healthcare systems in many low- and middle-income countries (LMICs), making it an essential partner in achieving universal health coverage (UHC)
Anne-Sophie Jung, Nuhu Yaqub, Samantha R. Lattof, Joe Strong, Blerta Maliqi   +4 more
doaj   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Blockchain-Secured Digital Twin Framework for Fuzzy Multi-Objective Optimization in Supply Chain Finance

FinTech
This research presents an integrated framework for supply chain finance in which digital twin, blockchain, and multi-objective fuzzy optimization are used in synergy to improve financial decision-making in dynamic and uncertain environments.
Hamed Nozari, Zornitsa Yordanova
doaj   +1 more source

Putting the Prosecutor on a Clock? Responding to Variance in the Length of Preliminary Examinations

AJIL Unbound, 2018
One of the unique challenges that the International Criminal Court's (ICC's) Office of the Prosecutor (OTP) faces is deciding when and where to launch investigations. It is a task that other international prosecutors have not confronted.
David Bosco
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source