Results 31 to 40 of about 159,884 (253)
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Vallis Aurea, 2015 The Agreement on Trade Related Aspects of Intellectual Property Rights is one of the recent treaties in the system of intellectual property protection. This agreement represents an annex to the Agreement Establishing the World Trade Organization and is ...
Jovan Sarac
doaj +1 more source
Transformation of Foreign Trade Business Strategies in the Face of Sanctions Pressure
Современная конкуренция, 2022 The pandemic caused by the SARS-CoV-2 coronavirus (COVID-19) has not only led to economic stagnation, border closures and a serious reduction in cross-border activities, but has also effectively paralyzed international trade ties.
Irina F. Zhuckovskaya
doaj +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
DOKTRIN WIRAUSAHA ALA RASÛLULLÂH
Al-Ihkam: Jurnal Hukum dan Pranata Sosial, 2013 Indonesia face the challenge of economy globalization era that is free trade system that has been agreed by the world. Trade system and free-opened investment becomes global commitment signed by agreement of GATT (General Agreement on Tariffs and Trade ...
Farid Firmansyah
doaj +3 more sources
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Meridiano 47, 2017 The author presents the evolution of the multilateral trading system since the creation of the General Agreement on Tariffs and Trade (GATT), in 1947, to the current challenges of the Doha Round of the World Trade Organization (1995).
Paulo Roberto de Almeida
doaj
Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function
FEBS Open Bio, EarlyView.We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke +4 more
wiley +1 more source
The challenges of the World Trade Organization
Meridiano 47, 2017 The author appraises the current World Trade Organization identity crises. He evaluates the difficulties in concluding the Doha Round, the challenge of regional trade agreements and governance issues, particularly those related to new themes.
Rubens Antônio Barbosa
doaj