Results 111 to 120 of about 206,945 (300)
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Fight or Buy Bonds, World War I poster
, 2019 This poster from World War I depicts a woman waving a United States flag while soldiers march behind her.
Christy, Howard Chandler, 1873-1952, artist
core
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
World War I officer T. Randolph Perkinson, Jr., 1917
, 1917 1st Lieutenant T. Randolph Perkinson, Jr., Class of 1918, in during World War I.
core
World War I and the space-time-war nexus
Stating that World War I is both distant and near to us may be seen as both an oxymoron and a truism. The centenary of the conflict was a reminder of the temporal distance that exists between us and the people who fought in that war. In that sense, World
Robertson, Emily, Fathi, Romain
core +1 more source
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
Sure! We'll Finish the Job, World War I poster
, 2019 This poster from World War I depicts a man in overalls and a hat.
Beneker, Gerrit A. (Gerrit Albertus), 1882-1934, artist
core
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
The Spirit of America, World War I poster
, 2019 This poster from World War I depicts a nurse draped in the American flag, while promoting the Red Cross Home Service ...
Christy, Howard Chandler, 1873-1952, artist
core
FEBS Letters, EarlyView.The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson +6 more
wiley +1 more source