Results 71 to 80 of about 1,817,802 (357)
Cyclic nucleotide signaling as a drug target in retinitis pigmentosa
FEBS Letters, EarlyView.Disruptions in cGMP and cAMP signaling can contribute to retinal dysfunction and photoreceptor loss in retinitis pigmentosa. This perspective examines the mechanisms and evaluates emerging evidence on targeting these pathways as a potential therapeutic strategy to slow or prevent retinal degeneration.
Katri Vainionpää +2 more
wiley +1 more source
BMGN: Low Countries Historical Review, 2004 J. Meihuizen, Noodzakelijk kwaad. De bestraffing van economische collaboratie in Nederland na de Tweede WereldoorlogThe economy and full-scale warMeihuizen concludes that the interests of the reconstruction had to take precedence over those of an ...
H.A.M. Klemann
doaj +3 more sources
FEBS Letters, EarlyView.Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu +17 more
wiley +1 more source
FEBS Letters, EarlyView.Three‐dimensional (3D) biological systems have become key tools in lymphoma research, offering reliable in vitro and ex vivo platforms to explore pathogenesis and support precision medicine. This review highlights current 3D non‐Hodgkin lymphoma models, detailing their features, advantages, and limitations, and provides a broad perspective on future ...
Carla Faria +3 more
wiley +1 more source
From omics to AI—mapping the pathogenic pathways in type 2 diabetes
FEBS Letters, EarlyView.Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan +2 more
wiley +1 more source
Wars, disasters and kidneys [PDF]
, 2014 This paper summarizes the impact that wars had on the history of nephrology, both worldwide and in the Ghent Medical Faculty notably on the definition, research and clinical aspects of acute kidney injury.
Lameire, Norbert
core +2 more sources
The anabolic steroid stanozolol is a potent inhibitor of human MutT homolog 1
FEBS Letters, EarlyView.MutT homolog 1 (MTH1) is a member of the NUDIX superfamily of enzymes and is an anticancer drug target. We show that stanozolol (Stz), an anabolic steroid, is an unexpected nanomolar inhibitor of MTH1. The X‐ray crystal structure of the human MTH1–Stz complex reveals a unique binding scaffold that could be utilized for future inhibitor development ...
Emma Scaletti Hutchinson +7 more
wiley +1 more source
BMGN: Low Countries Historical Review, 2004 Reaction to Buyst and Lefebvre I only partly agree with Buyst and Lefebvre’s contention that I am no longer interested in treating the problems of collaboration and resistance as a key subject in World War II history.
H.A.M. Klemann
doaj +3 more sources
, 2017 Review of Lawrence Klippenstein, Peace and War, Mennonite Conscientious Objectors in Tsarist Russia and the Soviet Union before World War II, and other COs in Eastern Europe, Winnipeg, MB. 2017. 367pp.
Friesen, John J.
core
Drummond Family Military Uniforms Collection - Accession 1572 [PDF]
, 2018 The Drummond Family Military Uniforms Collection consists of uniforms worn by Warren Howell Drummond (1889-1950) and James Drummond. Warren Howell Drummond served in the US Navy during World War I and the collection contains his jacket, belt and pants ...
Drummond, James +3 more
core +1 more source