Results 301 to 310 of about 1,010,075 (360)

Co‐Opting MBNL‐Dependent Alternative Splicing Cassette Exons to Control Gene Therapy in Myotonic Dystrophy

Annals of Neurology, EarlyView.
Objective Myotonic dystrophy type 1 (DM1) is a highly variable, multisystemic genetic disorder caused by a CTG repeat expansion in the 3′ untranslated region of DMPK. Toxicity is exerted by repeat‐containing DMPK transcripts that sequester muscleblind‐like (MBNL) proteins and lead to deleterious yet predictable changes in alternative splicing.
Samuel T. Carrell, Ellie M. Carrell, Ryan Giovenco, Beverly L. Davidson   +3 more
wiley   +1 more source

Primary care patients' perspectives on CT coronary calcium scoring and exercise electrocardiography. [PDF]

Eur J Gen Pract
Koopman M, Willemsen R, Doggen C, Kietselaer B, van Ooijen P, Gratama JW, Braam R, Dinant GJ, van Bruggen R, van der Harst P, Vliegenthart R.   +10 more
europepmc   +1 more source

Beta Power Response After Levodopa Intake in Parkinson's Disease Patients With Chronic Sensing‐Enabled Deep Brain Stimulation

Annals of Neurology, EarlyView.
Objective In Parkinson's disease (PD), the power of beta oscillations (± 13–30 hertz [Hz]) from subthalamic nucleus (STN) local field potentials (LFPs) is associated with motor symptoms. Beta power can be used for adaptive deep brain stimulation (aDBS) algorithms based upon symptom fluctuations.
Martijn G.J. de Neeling, Bart J. Keulen, Mariëlle J. Stam, Deborah Hubers, Rob M.A. de Bie, Bernadette C.M. van Wijk, P. Rick Schuurman, Arthur W.G. Buijink, Martijn Beudel   +8 more
wiley   +1 more source

Pain, Anger, and Rumination in Fibromyalgia: A Vicious Cycle? [PDF]

J Clin Med
Tenti M, Varallo G, Cilenti F, Raffaeli W, Scorza M, Rubichi S, Pietrabissa G, Castelnuovo G, Gremigni P, Casu G.   +9 more
europepmc   +1 more source

Chitosan Hydrogels Crosslinked With Glutaraldehyde for Potential Toxic Elements Removal: Batch and Purification Device Analysis

Journal of Applied Polymer Science, EarlyView.
ABSTRACT The presence of toxic metal ions in contaminated wastewater raises significant concerns for human health. Three‐dimensional porous systems like hydrogels are being explored for contaminant removal. Still, there is a lack of understanding of their production parameters and performance.
Rennan F. S. Barbosa, Sudip Shyam, Sirshendu Misra, Sushanta K. Mitra, Derval S. Rosa   +4 more
wiley   +1 more source

A network analysis of the depression and anxiety comorbidity: a nationwide survey among Chinese adolescents during the normalization phase of COVID-19 pandemic prevention and control. [PDF]

BMC Psychiatry
Li T, Zhang D, Jiang T, Che W, Zhang Y, Wan Y, Tao F, Tao S, Wu X.   +8 more
europepmc   +1 more source

“Visiting scientist effect”? Exploring the impact of time‐lags in the digitization of 2D landmark data

The Anatomical Record, EarlyView.
Abstract Measurement error (ME) in geometric morphometrics has been the subject of countless articles, but none specific to the effect of time lags on landmark digitization error. Yet, especially for visiting scientists working on museum collections, it is not uncommon to collect data in multiple rounds, with interruptions of weeks or years. To explore
Andrea Cardini
wiley   +1 more source

Out-of-pocket medical costs in relation to resection of colorectal liver metastases in the Australian healthcare system. [PDF]

Support Care Cancer
Bhimani N, Seton R, Chan D, Dieng M, Kelly PJ, Hugh TJ.   +5 more
europepmc   +1 more source

Association of worrier trait with the risk of Parkinson's disease: a longitudinal study based on 457,180 UK Biobank participants. [PDF]

Front Psychol
Li R, Ling Y, Pan A, Cao R, Lyu J, Bi W.
europepmc   +1 more source

Efficacy and Safety of ABBV‐154 for the Treatment of Active Rheumatoid Arthritis: A Phase 2b, Randomized, Placebo‐Controlled Trial

Arthritis &Rheumatology, EarlyView.
Objective Despite the availability of biologic and targeted synthetic disease‐modifying antirheumatic drugs (b/tsDMARDs) to treat rheumatoid arthritis (RA), many patients do not experience optimized disease control. Glucocorticoids are effective but have safety risks.
Frank Buttgereit, Atul Singhal, Alan Kivitz, Edit Drescher, Yoshinori Taniguchi, Rosalía Martínez Pérez, Jaclyn Anderson, Ronilda D'Cunha, Weihan Zhao, Nicholas DeVogel, Julie Parmentier, Romy Christmann, Dilek Arikan, Howard Amital   +13 more
wiley   +1 more source