Results 131 to 140 of about 199,627 (273)
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Noncompleted Matches in Professional Women's Tennis (1975-2024): Epidemiology, Trends, and Associated Factors of Walkovers and Defaults. [PDF]
Peña V, Baiget E, Pluim BM, Casals M.
europepmc +1 more source
In den mykenischen Texten kommt ein Wort wo-wo mehrfach vor. Das bisher publizierte Material zeigt es 26mal in Pylos und zweimal in Knossos. An allen Stellen mit Ausnahme von zweien wird es ?regelm?ssig?, d. h. mit den beiden nach rechts schauenden Zeichen wo hintereinander geschrieben; nur in PY Eb338.2 und E0278 ist das zweite Zeichen symmetrisch zum
openaire +1 more source
Tumor mutational burden as a determinant of metastatic dissemination patterns
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal +4 more
wiley +1 more source
CrossDI: A comprehensive dataset crossing three databases for calculating disruption indexes. [PDF]
Xu S, Wang C, An X, Liu J.
europepmc +1 more source
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Integrated geochemical and geophysical assessment for monitoring soil stabilization with waste oyster shells. [PDF]
Lee S, Kim M, Lee N, Ahn Y, Choi J.
europepmc +1 more source
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source

