Results 51 to 60 of about 1,024,527 (318)

The multiple roles of the NlpC_P60 peptidase family in mycobacteria – an underexplored target for antimicrobial drug discovery

FEBS Letters, EarlyView.
The NlpC_P60 superfamily of peptidases is recognised by its key role in bacterial cell wall homeostasis. Recently, studies have also described the involvement of NlpC_P60‐like enzymes in bacterial competitive mechanisms and pathogenesis across several lineages.
Catharina dos Santos Silva, Marcio Vinicius Bertacine Dias   +1 more
wiley   +1 more source

Glucocorticoid-mediated induction of caveolin-1 disrupts cytoskeletal organization, inhibits cell migration and re-epithelialization of non-healing wounds

Communications Biology, 2021
Jozic et al observe deregulated cytoskeleton components and elevated levels of cortisol and caveolin-1 in chronic wounds. They also show that inducible-keratinocyte specific Cav1 knockout or drug-induced cholesterol disruption in diabetic mice leads to ...
Ivan Jozic, Beatriz Abdo Abujamra, Michael H. Elliott, Tongyu C. Wikramanayake, Jelena Marjanovic, Rivka C. Stone, Cheyanne R. Head, Irena Pastar, Robert S. Kirsner, Fotios M. Andreopoulos, Juan P. Musi, Marjana Tomic-Canic   +11 more
doaj   +1 more source

Melatonin-stimulated MSC-derived exosomes improve diabetic wound healing through regulating macrophage M1 and M2 polarization by targeting the PTEN/AKT pathway

Stem cell research & therapeutics, 2020
Background After surgery, wound recovery in diabetic patients may be disrupted due to delayed inflammation, which can lead to undesired consequences, and there is currently a lack of effective measures to address this issue.
Wei Liu, Muyu Yu, D. Xie, Longqing Wang, Cheng Ye, Qi Zhu, Fang Liu, Lili Yang   +7 more
semanticscholar   +1 more source

Challenges in Healing Wound: Role of Complementary and Alternative Medicine

Frontiers in Nutrition, 2022
Although the word wound sounds like a simple injury to tissue, individual's health status and other inherent factors may make it very complicated. Hence, wound healing has gained major attention in the healthcare. The biology wound healing is precise and
P. Monika, M. N. Chandraprabha, A. Rangarajan, Prashant Waiker, K. C. Chidambara Murthy   +4 more
semanticscholar   +1 more source

Unlocking the potential of tumor‐derived DNA in urine for cancer detection: methodological challenges and opportunities

Molecular Oncology, EarlyView.
Urine is a rich source of biomarkers for cancer detection. Tumor‐derived material is released into the bloodstream and transported to the urine. Urine can easily be collected from individuals, allowing non‐invasive cancer detection. This review discusses the rationale behind urine‐based cancer detection and its potential for cancer diagnostics ...
Birgit M. M. Wever, Renske D. M. Steenbergen   +1 more
wiley   +1 more source

Protocol for a systematic review of the efficacy of fat grafting and platelet-rich plasma for wound healing

Systematic Reviews, 2017
Background The use of fat grafting as a reconstructive surgical option is becoming much more common. Adipose-derived stem cells found in fat grafts are believed to facilitate wound healing via differentiation into fibroblasts and keratinocytes and the ...
Oliver J. Smith, Muholan Kanapathy, Ankur Khajuria, Max Prokopenko, Nadine Hachach-Haram, Haroon Mann, Ash Mosahebi   +6 more
doaj   +1 more source

The Role of MSC in Wound Healing, Scarring and Regeneration

Cells, 2021
Tissue repair and regeneration after damage is not completely understood, and current therapies to support this process are limited. The wound healing process is associated with cell migration and proliferation, extracellular matrix remodeling ...
R. Guillamat-Prats
semanticscholar   +1 more source

Clinical applications of next‐generation sequencing‐based ctDNA analyses in breast cancer: defining treatment targets and dynamic changes during disease progression

Molecular Oncology, EarlyView.
Circulating tumor DNA (ctDNA) offers a possibility for different applications in early and late stage breast cancer management. In early breast cancer tumor informed approaches are increasingly used for detecting molecular residual disease (MRD) and early recurrence. In advanced stage, ctDNA provides a possibility for monitoring disease progression and
Eva Valentina Klocker, Samantha Hasenleithner, Rupert Bartsch, Simon P. Gampenrieder, Daniel Egle, Christian F. Singer, Gabriel Rinnerthaler, Michael Hubalek, Katja Schmitz, Zsuzsanna Bago‐Horvath, Andreas Petzer, Sonja Heibl, Ellen Heitzer, Marija Balic, Michael Gnant   +14 more
wiley   +1 more source

Fatigue is associated with disease severity in adult patients with hidradenitis suppurativa

JEADV Clinical Practice
Background Patients with hidradenitis suppurativa (HS) experience fatigue, but no studies have yet examined the association between HS severity and fatigue intensity.
Astrid Chodziuk, Nikolaj Holgersen, Valdemar W. Nielsen, Jacob P. Thyssen, Alexander Egeberg, Simon F. Thomsen   +5 more
doaj   +1 more source

All-in-One: Multifunctional Hydrogel Accelerates Oxidative Diabetic Wound Healing through Timed-Release of Exosome and Fibroblast Growth Factor.

Small, 2021
The treatment of diabetic wounds remains a major challenge in clinical practice, with chronic wounds characterized by multiple drug-resistant bacterial infections, angiopathy, and oxidative damage to the microenvironment.
Y. Xiong, Lang Chen, Pei Liu, Tao Yu, Chuanchuan Lin, Chenchen Yan, Yiqiang Hu, Wu Zhou, Yun Sun, Adriana C. Panayi, Faqi Cao, Hang Xue, Liangcong Hu, Ze Lin, Xudong Xie, X. Xiao, Q. Feng, B. Mi, Guohui Liu   +18 more
semanticscholar   +1 more source