Results 1 to 10 of about 303,966 (315)

Challenges in the management of chronic wound infections

Journal of Global Antimicrobial Resistance, 2021
: Objectives: Chronic wound infections may delay the healing process and are responsible for a significant burden on healthcare systems. Since inappropriate management may commonly occur in the care of these patients, this review aims to provide a ...
Marco Falcone, Barbara De Angelis, Federico Pea, Alessandro Scalise, Stefania Stefani, Rolando Tasinato, Orazio Zanetti, Luca Dalla Paola   +7 more
doaj   +3 more sources

Optomagnetic Imaging Spectroscopy (OMIS) for in situ detection of bacteria in blood – feasibility study

4 open, 2022
Introduction: Sepsis is one of the leading causes of death in military and civilian hospitals. Rapid identification of involved pathogens is a key step for appropriate diagnosis, treatment and ultimately survival.
Garry Brittany, Stoiljkovic Nikola, Jovic Zorana, Pavlovic Radmila, Getnet Derese, Demons Samandra T., Tyner Stuart D., Zurawski Daniel V., Swierczewski Brett E., Koruga Djuro, Bobrov Alexander G., Antonic Vlado   +11 more
doaj   +1 more source

Identification and Characterization of vB_PreP_EPr2, a Lytic Bacteriophage of Pan-Drug Resistant Providencia rettgeri

Viruses, 2022
Providencia rettgeri is an emerging opportunistic Gram-negative pathogen with reports of increasing antibiotic resistance. Pan-drug resistant (PDR) P.
Jaime L. Mencke, Yunxiu He, Andrey A. Filippov, Mikeljon P. Nikolich, Ashton T. Belew, Derrick E. Fouts, Patrick T. McGann, Brett E. Swierczewski, Derese Getnet, Damon W. Ellison, Katie R. Margulieux   +10 more
doaj   +1 more source

Minocycline and the SPR741 Adjuvant Are an Efficacious Antibacterial Combination for Acinetobacter baumannii Infections

Antibiotics, 2022
Antibiotic resistance, when it comes to bacterial infections, is not a problem that is going to disappear anytime soon. With the lack of larger investment in novel antibiotic research and the ever-growing increase of resistant isolates amongst the ...
Yonas A. Alamneh, Vlado Antonic, Brittany Garry, Michael J. Pucci, Rania Abu-Taleb, Jonathan P. Shearer, Samandra T. Demons, Derese Getnet, Brett E. Swierczewski, Troy Lister, Daniel V. Zurawski   +10 more
doaj   +1 more source

Longitudinal temperature measurement can determine humane endpoints in BALB/c mouse models of ESKAPEE infection

Virulence, 2023
Antimicrobial resistance (AMR) is a worldwide problem, which is driving more preclinical research to find new treatments and countermeasures for drug-resistant bacteria.
Randal Scott Dudis, Ting Y. Wong, Mariel G. Escatte, Yonas A. Alamneh, Rania Abu-Taleb, Wanwen Su, Christine Czintos, Timothy A. Fitzgerald, Yoann Le Breton, Daniel V. Zurawski   +9 more
doaj   +1 more source

Synergistic Killing and Re-Sensitization of Pseudomonas aeruginosa to Antibiotics by Phage-Antibiotic Combination Treatment

Pharmaceuticals, 2021
Multidrug-resistant (MDR) Pseudomonas aeruginosa infections pose a serious health threat. Bacteriophage–antibiotic combination therapy is a promising candidate for combating these infections. A 5-phage P.
Emily Engeman, Helen R. Freyberger, Brendan W. Corey, Amanda M. Ward, Yunxiu He, Mikeljon P. Nikolich, Andrey A. Filippov, Stuart D. Tyner, Anna C. Jacobs   +8 more
doaj   +1 more source

Hyphae of Rhizopus arrhizus and Lichtheimia corymbifera Are More Virulent and Resistant to Antifungal Agents Than Sporangiospores In Vitro and in Galleria mellonella

Journal of Fungi, 2023
Mucorales species cause debilitating, life-threatening sinopulmonary diseases in immunocompromised patients and penetrating wounds in trauma victims. Common antifungal agents against mucormycosis have significant toxicity and are often ineffective.
Rex Jeya Rajkumar Samdavid Thanapaul, Ashleigh Roberds, Kariana E. Rios, Thomas J. Walsh, Alexander G. Bobrov   +4 more
doaj   +1 more source

Blast Waves Cause Immune System Dysfunction and Transient Bone Marrow Failure in a Mouse Model

Frontiers in Bioengineering and Biotechnology, 2022
Explosive devices, either conventional or improvised, are common sources of injuries during combat, civil unrest, and terror attacks, resulting in trauma from exposure to blast.
Elke S. Bergmann-Leitner, Alexander G. Bobrov, Jessica S. Bolton, Michael D. Rouse, Michael D. Rouse, Lanier Heyburn, Radmila Pavlovic, Brittany I. Garry, Yonas Alamneh, Joseph Long, Brett Swierczewski, Stuart Tyner, Derese Getnet, Venkatasivasai S. Sajja, Vlado Antonic   +14 more
doaj   +1 more source

Whole-cell vaccine candidates induce a protective response against virulent Acinetobacter baumannii

Frontiers in Immunology, 2022
Acinetobacter baumannii causes multi-system diseases in both nosocomial settings and a pre-disposed general population. The bacterium is not only desiccation-resistant but also notoriously resistant to multiple antibiotics and drugs of last resort ...
Stephen J. Dollery, Daniel V. Zurawski, Ruth V. Bushnell, John K. Tobin, Taralyn J. Wiggins, David A. MacLeod, Naomi J. P. E. R. Tasker, Yonas A. Alamneh, Rania Abu-Taleb, Christine M. Czintos, Wanwen Su, Mariel G. Escatte, Heather N. Meeks, Michael J. Daly, Gregory J. Tobin   +14 more
doaj   +1 more source

Design of a Bacteriophage Cocktail Active against Shigella Species and Testing of Its Therapeutic Potential in Galleria mellonella

Antibiotics, 2022
Shigellosis is a leading global cause of diarrheal disease and travelers’ diarrhea now being complicated by the dissemination of antibiotic resistance, necessitating the development of alternative antibacterials such as therapeutic bacteriophages (phages)
Andrey A. Filippov, Wanwen Su, Kirill V. Sergueev, Richard T. Kevorkian, Erik C. Snesrud, Apichai Srijan, Yunxiu He, Derrick E. Fouts, Woradee Lurchachaiwong, Patrick T. McGann, Damon W. Ellison, Brett E. Swierczewski, Mikeljon P. Nikolich   +12 more
doaj   +1 more source