Penetrating extremity injuries in a large Scandinavian Level-1 trauma center: a 4-year analysis of imaging methods, mechanisms of injury and clinical outcome. [PDF]
Cewe P +7 more
europepmc +1 more source
Cortical Response to Acute Implantation of the Utah Optrode Array in Macaque Cortex
Delivering light deep into the brain over a large volume while causing minimal tissue damage is a major challenge for non‐human primate optogenetics. This study evaluates Utah Optrode Array designs in vivo, revealing how changes in shank geometry, surface texture, and insertion parameters minimize acute damage—offering a path toward high‐precision ...
Adrián Villamarin‐Ortiz +8 more
wiley +1 more source
Clinical presentation and management outcome of abdominal stab wounds in a low-resource setting: experience of a central hospital in Sudan. [PDF]
Saadeldien MSM +4 more
europepmc +1 more source
In a murine model of acute lung injury, pulmonary administration of lipid nanoparticles carrying TNFα siRNA enables targeted delivery to immune cells. The study emphasises the importance of optimizing LNP distribution and delivery timing to improve therapeutic outcomes and develop emergency therapies for lung hyperinflammation.
Qinglin Wang +14 more
wiley +1 more source
Assessing fishery interaction on cetaceans stranded along the Italian coastline between 1986 and 2023. [PDF]
Pietroluongo G +32 more
europepmc +1 more source
Multifunctional Biomedical Devices with Closed‐Loop Systems for Precision Therapy
This review explores two major types of closed‐loop therapeutic systems: self‐sustained and externally triggered. It highlights recent advances in stimuli‐responsive materials, integrated bioelectronics, and data‐driven control strategies, offering insight into emerging strategies for personalized, responsive drug delivery.
Yixuan Leng, Rujie Sun
wiley +1 more source
Cell Surface Thiol Engineering Mechanoregulates Myogenic Differentiation via the FAK–PI3K–AKT Axis
Schematic diagram illustrating how cell surface modification of skeletal muscle progenitor cells through TCEP treatment reveals enhanced cell adhesion, intracellular tension, and myogenesis at 19.66 kPa stiffness, leading to optimal cell fusion. In contrast, no significant changes are observed in the softer (10.61 kPa) or stiffer (49.4 kPa) matrices ...
Juyeon Kim +10 more
wiley +1 more source
PENETRATING WOUNDS OF THE ORBIT [PDF]
openaire +3 more sources
Rolling Ultrasharp Microneedle Spheres Enable Topical Delivery of Biologics Through the Skin
Rolling ultraminiaturized microneedle spheres (RUMS), created via two‐photon polymerization, unlock effective and painless topical delivery of messenger RNA (mRNA) and drugs through the skin. By gently forming thousands of microscopic pores, RUMS boost skin permeability by up to 100‐fold.
Theocharis Nikiforos Iordanidis +6 more
wiley +1 more source

