Results 31 to 40 of about 282 (166)

La relación literaria de Ramón Gómez de la Serna y de Valery Larbaud. Contribución a un nuevo acercamiento según los epistolarios de algunos de los «Potassons» [PDF]

open access: yesÇédille: Revista de Estudios Franceses, 2011
It is a well known fact that Ramon Gómez de la Serna reached his international dimension with the help of his first critic and translator. Valery Larbaud with a great enthusiasm and devotion, helped by his European and international vision of literature,
María Isabel Corbí Sáez
doaj  

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

open access: yesFEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara   +3 more
wiley   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

open access: yesMolecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain   +10 more
wiley   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

open access: yesMolecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen   +9 more
wiley   +1 more source

La femme et l’œuvre: Robbe-Grillet [PDF]

open access: yesÇédille: Revista de Estudios Franceses, 2013
This article deals with recent publica-tions (2012) on Alain Robbe-Grillet’s work: a collection of letters and a biographical piece published by the writer’s widow, Catherine Robbe-Grillet.
José María Fernández Cardo
doaj  

Fedor Dostoevsky. Suffering, clothed in flesh

open access: yesЯзык и текст, 2018
In the article a difficult period of the writer's life is considered - the period of travels to Italy, when the writer was forced to turn to all kinds and sources of earnings in order to somehow maintain his good name.
S.M. Makhmudova, A.V. Pavlyuk
doaj   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

open access: yesFEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point   +7 more
wiley   +1 more source

The Falsifications of Isaac Babel's Manuscripts and Their Recognition [PDF]

open access: yesЛитературный факт
The article is dedicated to the handwritten legacy of Isaac Babel and examines the writer’s letters, inscriptions, and drawings introduced into scientific circulation in the last decade. Based on the analysis of these findings, the article concludes that
Petr A. Druzhinin
doaj   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

open access: yesFEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli   +8 more
wiley   +1 more source

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