Results 111 to 120 of about 16,766 (299)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
An approach of bio-inspired generalized shape for writer identification [PDF]
, 2006 Writer identification is one of the areas that attract many researchers to work in. It has being focus in forensic and biometric application where the writing styles can be used as biometric features for authenticating an identity. The individualistic of
Muda , Azah Kamilah +1 more
core
Вестник Кемеровского государственного университета, 2015 The paper deals with the strategy of G. Grebenshchikov’s auto-myth-making. The beginner Siberian writer constructed a myth about «a writer from the common people», using which he accomplished the task of entering the literary world.
A. Yu. Gorbenko
doaj
OHSCR: Benchmarks Dataset for Offline Handwritten Sindhi Character Recognition
Sir Syed University Research Journal of Engineering and TechnologyThis research work presents a unique dataset for offline handwritten Sindhi character recognition. It has 7800 character images in total, divided into multiple categories by 150 writers of various ages, genders, and professional backgrounds. Each writer
Jakhro Abdul Naveed +3 more
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Hipogrifo: Revista de Literatura y Cultura del Siglo de OroThis paper presents a computational approach for detecting the calligraphic footprint of a scribe in a large documentary corpus. The system leverages advances in HTR (Handwritten Text Recognition) techniques, usually employed for automatic transcription,
Álvaro Cuéllar, Sònia Boadas
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Bio-inspired generalized global shape approach for writer identification [PDF]
, 2006 Writer identification is one of the areas in pattern recognition that attract many researchers to work in, particularly in forensic and biometric application, where the writing style can be used as biometric features for authenticating an identity.
Draman @ Muda, Azah Kamilah +5 more
core
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source