Results 81 to 90 of about 800,572 (280)
Reliable signature authentication is essential across fields where identity verification is critical. Despite advances in machine learning, validating handwritten signatures remains challenging due to inherent variability in individual writing styles ...
Giovanni Piccinini +2 more
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Algo más sobre La grande de Saer: Experimentación y programa novelescos
The verification of a recent change in the ways of reading Juan José Saer's works is the starting point in this article, towards a query on the topicality of his critical agenda.
Rafael Arce
doaj
“NO PICTURES, PLEASE”. JOSÉ LUÍS PEIXOTO’S JOURNEY IN NORTH KOREA
In 2012, the Portuguese writer José Luís Peixoto travelled to North Korea and the result of this trip was the travel account Dentro do Segredo [Inside the Secret].
Catarina Nunes de Almeida
doaj
Formal Verification of a Reader-Writer Lock Implementation in C
AbstractWe present the formal verification of a reader-writer lock implementation, which is a widely used synchronization primitive in multithreaded code. Specifications are given at the level of C code in the annotation language of Microsoft's Verifying C Compiler (VCC); VCC generates and discharges all verification conditions automatically.
Mark A. Hillebrand, Dirk Leinenbach
openaire +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
The current issue on international education, especially in relation with muslim community, like in Malaysia and Indonesia is morality. The impact and influence of secular civilization upon muslim society can not be denied. The problem of morality is not
Imam Bahroni
doaj +1 more source
An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source

