Results 151 to 160 of about 1,471,455 (310)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

Writing at work: Transfer of genre knowledge to research writing in the medical field [PDF]

open access: yes, 2018
Transfer is often defined in terms of “transfer of knowledge” and “knowledge transformation” (Donahue, 2016). Transfer is a complex concept, operationalized as “near” vs. “far” transfer—referring to the proximity between context and tasks, and “high-road”
Gustafsson, Magnus,   +1 more
core  

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

open access: yesMolecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic   +5 more
wiley   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

open access: yesMolecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni   +11 more
wiley   +1 more source

Differing social positions and the realisation of evaluative criteria for transactional writing in the senior grades [PDF]

open access: yes, 2012
Includes abstract.Includes bibliographical references.This study looked at the requirements - evaluative criteria - for transactional writing as they are specified for the Grade 11 level in current curriculum policy.
Kruger, Jared James
core  

Help Me Write a Story: Evaluating LLMs’ Ability to Generate Writing Feedback

open access: yesProceedings of the 63rd Annual Meeting of the Association for Computational Linguistics (Volume 1: Long Papers)
ACL 2025 main ...
Hannah Rashkin   +3 more
openaire   +3 more sources

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

open access: yesMolecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera   +11 more
wiley   +1 more source

An Investigation into the English Academic Writing Strategies Employed by Students of HE in the NE of England with Particular Reference to their Nationalities and Gender [PDF]

open access: yes
The research compared native (NSE) and non-native (NNSE) learners' academic writing strategies in higher education (HE), where natives are learners who were born and educated in Britain, and non-native participants are nationals of Mainland China and ...
Abdul-Rahman, Seham Sassi
core  

THINK TALK WRITE STRATEGY ON STUDENTS’ WRITING ABILITY

open access: yesJETA (Journal of English Teaching and Applied Linguistic)
: Speaking skills are skills that enable us to communicate effectively.  This skill has the most important goal for student success, especially for class XI of SMA because they will face the era of globalization in the world.  As for the problems faced by class XI students of SMA Darus Su'ada Al-Ahad, most of them are not able to speak English.
openaire   +1 more source

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