Results 51 to 60 of about 468,667 (249)
OBJETIVO: Propor um modelo estruturado para a elaboração das respostas às solicitações de pareceres psiquiátricos no hospital geral e discutir seus aspectos fundamentais. MÉTODOS: Foi realizada uma pesquisa sistemática nas bases de dados PubMed/Medline e
Antonio Leandro Nascimento +3 more
doaj +1 more source
Developing Mathematics Written Communication through Case-Based Learning
Mathematical education, as it is now practiced, has many problems. Students that were taught using traditional instruction were only taught to listen. Without the input and feedback of the pupils, the teacher controls the learning process.
Joko Suratno +2 more
doaj +1 more source
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
أثر النص التمثيلي في تنمية مهارات التواصل اللغوي لدى تلاميذ الصف الخامس الابتدائي [PDF]
هدفت هذه الدراسة إلى تعرف أثر النص التمثيلي في تنمية مهارات التواصل اللغوي لدى تلاميذ الصف الخامس الابتدائي، وقد استخدم الباحث المنهج التجريبي في تصميمه شبه التجريبي القائم على مجموعتين: تجريبية وضابطة، وتکون مجتمع الدراسة من جميع تلاميذ الصف الخامس ...
نايف مقعد مصلح العتيبي
doaj +1 more source
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Analysis of students' writing ability using concept maps based on Dienes’ theory
As one of the important aspects in learning, both written and oral, communication is obtained from how students express their ideas. One of them is by using a concept map that is compiled using relevant theoretical references.
Alfiani Athma Putri Rosyadi +3 more
doaj +1 more source

