Results 91 to 100 of about 2,779,130 (300)
Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
FEBS Letters, EarlyView.Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source
Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
Duality Theory for Variable Costs in Joint Production [PDF]
Duality methods for incomplete systems of consumer demand equations are adapted to the dual structure of variable cost functions in joint production. This allows the identification of necessary and sufficient restrictions on technology and cost so that ...
Jeffrey LaFrance, Rulon Pope
core
A escrita de estudantes pré-universitários: representação e estereotipia
Filologia e Linguística Portuguesa, 2006 The objective of this article is to present a first approach to a of short essays written by successful applicants in the first part entrance exam.
Helena Hathsue Nagamine Brandão
doaj +1 more source
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
Expression de la spatialité dans l’interlangue d’apprenants arabophones du français LE [PDF]
Revue Roumaine d’Etudes Francophones, 2019 Non-Francophone learners make use of their LM more or less consciously when learning (FLE). Our analysis focuses on the narration of a filmic support. It consists in disentangling the expression of spatiality in the inter-language of our learners.
Feiza AICHOUR
doaj
Recent advances in natural language processing (NLP) have contributed to the development of automated writing evaluation (AWE) systems that can correct grammatical errors. However, while these systems are effective at improving text, they are not optimally designed for language learning.
Steven Coyne +6 more
openaire +2 more sources
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
The Mysteries of a London Convent [transcript] [PDF]
Published in The London Miscellany and written by William Heard Hillyard (1811-1870), this 22 chapter story must have been considered a guaranteed blockbuster with the newspaper’s intended reading audience.
Hillyard, William H.
core +1 more source