Results 41 to 50 of about 649 (84)

Photo‐BQCA: Positive Allosteric Modulators Enabling Optical Control of the M1 Receptor

Angewandte Chemie International Edition, Volume 63, Issue 47, November 18, 2024.
Photoswitchable allosteric modulators for the Class A of a G protein‐coupled receptor, themuscarinic acetylcholine receptor subtype 1 (M1R) were developed based on the allosteric modulator benzyl quinolone carboxylic acid (BQCA) exploiting its flat structure–activity relationships.
Hubert Gerwe, Eva Schaller, Rosalba Sortino, Ekin Opar, Joaquín Martínez‐Tambella, Marcel Bermudez, J. Robert Lane, Pau Gorostiza, Michael Decker   +8 more
wiley   +1 more source

High Frequency of Cognitive and Behavioral Impairment in Amyotrophic Lateral Sclerosis Patients with SOD1 Pathogenic Variants

Annals of Neurology, Volume 96, Issue 1, Page 150-158, July 2024.
Objective While the cognitive‐behavioral characteristics of amyotrophic lateral sclerosis (ALS) patients carrying C9orf72 pathological repeat expansion have been extensively studied, our understanding of those carrying SOD1 variants is mostly based on case reports. The aim of this paper is to extensively explore the cognitive‐behavioral characteristics
Andrea Calvo, Cristina Moglia, Antonio Canosa, Umberto Manera, Rosario Vasta, Maurizio Grassano, Margherita Daviddi, Filippo De Mattei, Enrico Matteoni, Salvatore Gallone, Maura Brunetti, Luca Sbaiz, Sara Cabras, Laura Peotta, Francesca Palumbo, Barbara Iazzolino, Gabriele Mora, Adriano Chiò   +17 more
wiley   +1 more source

Diet quality and blood pressure among pregnant women with overweight or obesity: A secondary analysis of two randomized controlled trials

Acta Obstetricia et Gynecologica Scandinavica, Volume 103, Issue 6, Page 1073-1082, June 2024.
Among women with overweight and obesity, diet quality as quantified by AHEI‐P score had no association with blood pressure in either the first or early third trimesters. Abstract Introduction Maternal obesity is a significant risk factor for hypertensive disorders of pregnancy.
Sorcha Lynch, Sarah Louise Killeen, Eileen O'Brien, Kate Mullane, Emma Hokey, Grace Mealy, Fionnuala M. McAuliffe   +6 more
wiley   +1 more source

Ketocarotenoid production in tomato triggers metabolic reprogramming and cellular adaptation: The quest for homeostasis

Plant Biotechnology Journal, Volume 22, Issue 2, Page 427-444, February 2024.
Summary Plants are sessile and therefore have developed an extraordinary capacity to adapt to external signals. Here, the focus is on the plasticity of the plant cell to respond to new intracellular cues. Ketocarotenoids are high‐value natural red pigments with potent antioxidant activity.
Marilise Nogueira, Eugenia M. A. Enfissi, Elliott J. Price, Guillaume N. Menard, Eudri Venter, Peter J. Eastmond, Einat Bar, Efraim Lewinsohn, Paul D. Fraser   +8 more
wiley   +1 more source

Wymiary współpracy z rodzicami uczniów o specjalnych potrzebach edukacyjnych w przestrzeni pracy nauczyciela klas I–III

Szkoła - Zawód - Praca
W niniejszym artykule poruszono temat współpracy nauczyciela z rodzicami uczniów o specjalnych potrzebach edukacyjnych lokowanej w przestrzeni pracy nauczyciela.
Agnieszka Kaczor
doaj   +1 more source

The Unique Nature of School Cooperation with Parents of Children at the First Stage of Education: Opportunities – Difficulties – Needs

Studia Paedagogica Ignatiana, 2019
The family and school environment influence the upbringing and develop­ment of every human being. The process of the proper preparation of a child for life is only possible when both parties – parents and teachers – find the common ground necessary for ...
Marta Buk-Cegiełka
doaj   +1 more source

Improving digestibility of sorghum proteins by CRISPR/Cas9‐based genome editing

Food and Energy Security, Volume 13, Issue 1, January/February 2024.
Single‐consensus guide RNA partially reduces kafirin levels in sorghum (Sorghum bicolor) grain, leading to an increased proportion of non‐kafirins and improved digestibility and protein quality. This is the first study for improving digestibility of sorghum by genome editing‐kafirin encoded gene, K2G, and pollen mediated transformation method ...
Xinyu Li, Wenzhen Liu, Gaoliang Wang, Samuel Sai‐Ming Sun, Ling Yuan, Jingxue Wang   +5 more
wiley   +1 more source

Reproductive biology of the electric lanternfish Electrona risso (Myctophidae) and the bigscale fishes Melamphaes polylepis and Scopelogadus mizolepis (Melamphaidae)

Journal of Fish Biology, Volume 104, Issue 1, Page 252-264, January 2024.
Abstract This study was the first to investigate the key reproductive traits of the electric lantern fish Electrona risso (Myctophidae, n = 918) and the bigscale fishes (Melamphaidae) Melamphaes polylepis (n = 260) and Scopelogadus mizolepis (n = 649). Specimens of these mesopelagic species were collected in March and April 2015 in the eastern Central ...
Alexander H. Knorrn, Kim L. Wieben, Heino O. Fock, Henrike Andresen   +3 more
wiley   +1 more source

Współpraca wydziałów wyznaniowych państw bloku wschodniego (wspólne narady)

Archiwa, Biblioteki i Muzea Kościelne, 2018
Państwa socjalistyczne od początku lat 60 do końca istnienia bloku wschodniego, podjęły współpracę w kwestiach dotyczących polityki wyznaniowej. Wyrazem tej współpracy były organizowane wspólne narady urzędników wyznaniowych z krajów bloku wschodniego ...
Dominik Zamiatała
doaj   +1 more source

Identyfikacja i charakterystyka wybranych organizacji pozarządowych działających w obszarze bezpieczeństwa w Polsce

Roczniki Nauk Społecznych
Ze względu na dynamiczny rozwój technologii i ewolucję charakteru zagrożeń zarządzanie kryzysowe w Polsce staje się coraz bardziej złożonym zadaniem, wymagającym współpracy między różnymi podmiotami.
Grzegorz Milewski
doaj   +1 more source