Results 111 to 120 of about 620,051 (323)

Bufalin Inhibits the PI3K/AKT Pathway by Targeting GTF3C4 to Impede Breast Cancer Progression

open access: yesAdvanced Science, EarlyView.
Mechanisms of Bufalin‐Mediated Intervention in Breast Cancer. ABSTRACT Breast cancer incidence is rising globally, presenting challenges such as treatment side effects and drug resistance. Bufalin is a bufadienolides compound with potential anti‐cancer effects. This study shows that bufalin inhibits malignant proliferation of MDA‐MB‐231 and MCF‐7 cells
Siyu Guo   +15 more
wiley   +1 more source

Akıllı Kentlerin Gelişiminde Covid-19 Etkisi

open access: yesYüzüncü Yıl Üniversitesi Sosyal Bilimler Enstitüsü Dergisi, 2020
Günümüzde şehirler, Covid-19 salgını sonrası sürdürülebilir kalkınma için planlama perspektifinde bir değişikliğe ihtiyaç duymaktadır. Akıllı şehir kavramı, Türkiye’deki birçok orta ölçekli şehre böyle bir değişim için fırsatlar sunmaktadır.
Rukiye Gizem Öztaş Karlı   +1 more
doaj  

Ovarian Matrisome Dynamics and αvβ3‐Mediated Regulation in Early Follicular Development

open access: yesAdvanced Science, EarlyView.
The matrisome undergoes dynamic remodeling during early follicular development. Integrin αvβ3 mediates matrisome signals, regulating primordial follicle activation/atresia and secondary follicle growth via Hippo/mTOR pathways, with conserved roles in human ovaries, offering therapeutic targets for ovarian disorders.
Tong Wu   +12 more
wiley   +1 more source

Thermal Plasticity is Regulated by a Key MicroRNA During Range Expansion of an Invasive Fruit Fly

open access: yesAdvanced Science, EarlyView.
Populations at the invasion front of Bactrocera dorsalis adapt through reduced phenotypic and gene expression plasticity, a phenomenon likely to be driven by genetic assimilation. We identify a key miRNA‐mediated regulatory axis, in which miR‐276b post‐transcriptionally represses thw, a conserved chitin‐binding gene critical to the cold‐tolerance ...
Yan Zhao   +5 more
wiley   +1 more source

Cancer Cell‐Intrinsic Cholesterol Induces Lipid‐Associated Macrophage Differentiation via SP1 Palmitoylation to Promote Prostate Cancer Progression

open access: yesAdvanced Science, EarlyView.
Cancer cell‐intrinsic cholesterol promotes the S‐palmitoylation of SP1, increasing its nuclear translocation and driving the transcription and secretion of MDK, which in turn facilitates the differentiation of macrophages into a lipid‐associated phenotype.
Shirong Peng   +12 more
wiley   +1 more source

International Conference on Irrigation Management Transfer, Wuhan, China, 20-24 September 1994. Vol.2. Draft conference papers. [PDF]

open access: yes
IndonesiaAustraliaIndiaSri LankaNigeriaVietnamBangladeshDominican RepublicTanzaniaNigerPhilippinesColombiaEgyptUzbekistanPeruNepalMexicoThailandIrrigation managementDamsLocal managementPrivatizationWater users' associationsWater distributionCanal ...
IIMI   +1 more
core  

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