Results 121 to 130 of about 620,051 (323)

A Novel Function of Nonadecanoic Acid in Regulating Glucose Homeostasis

Advanced Science, EarlyView.
This study identifies the odd‐chain fatty acid C19:0 as an endogenous ligand of GPR120 that promotes glucose homeostasis via Gαq signaling. In obesity, elevated palmitic acid suppresses endogenous C19:0 production through a miRNA–PPARα–HACL1 pathway, offering a promising direction for understanding the role of OCFAs in human health.
Yanting Hou, Yinghua Ma, Qin Liu, Dingling Ma, Yuxin Tong, Lili Xu, Xiaolong Chu, Jingzhou Wang, Maodi Liang, Mengyuan Zhao, Huizi Zhang, Yurui Su, Jianxin Xie, Cuizhe Wang, Jun Zhang   +14 more
wiley   +1 more source

PERSPECTIVES AND HEALTH ANXIETIES OF GYNECOLOGICAL AND OBSTETRIC PATIENTS DURING NOVEL COVID- 19 PANDEMIC AT A TERTIARY CARE CENTRE

Pakistan Armed Forces Medical Journal, 2020
Objective: To assess the perspectives and health anxieties of gynecological and obstetric patients during Covid-19 pandemic. Study Design: Cross-sectional study.
Farhat Karim, Sadia Fatima, Uzma Saleem, Nusrat Noor, Rabia Kanwal   +4 more
doaj  

Investigation and Analysis of Changqing Campus of Wuhan Polytechnic University Based on Traffic Distribution [PDF]

, 2015
Huiyan Zhao
openalex   +1 more source

Testicular mRNA‐LNP Delivery: A Novel Therapy for Genetic Spermatogenic Disorders

Advanced Science, EarlyView.
In the current study, we developed a novel therapy for genetic spermatogenic disorders. It was revealed that in vivo delivery of mRNA LNP3 could restore spermatogenesis in Msh5D486Y/D486Y and Maps KO mouse models with meiotic arrest. Notably, the offspring without genomic integration was born using ICSI derived from the rescue of Msh5D486Y/D486Y mouse ...
Chenwang Zhang, Nan Liang, Wenbo Li, Shuai Xu, Peng Li, Wanze Ni, Na Li, Sha Han, Ningjing Ou, Haowei Bai, Yuxiang Zhang, Furong Bai, Yifan Sun, Dewei Qian, Xinjie Bu, Erlei Zhi, Ruhui Tian, Yuhua Huang, Jingpeng Zhao, Fujun Zhao, Hao Chen, Zheng Li, Chencheng Yao   +22 more
wiley   +1 more source

Nonlinear Effects of the Built Environment on Public Transit and Private Vehicle Mode Choices: A Trip Chain Perspective

Redai dili
Public transportation is a vital means to alleviate urban congestion. Despite substantial investments in public transit infrastructure in China, the development of urban public transportation has been unsatisfactory, with many city residents still ...
Liu Chang, Guo Liang, Yang Shuo, Zhang Qinghao, He Hui   +4 more
doaj   +1 more source

Lactylation‐Driven YTHDC1 Alleviates MASLD by Suppressing PTPN22‐Mediated Dephosphorylation of NLRP3

Advanced Science, EarlyView.
In MASLD, YTHDC1 undergoes increased lactylation and ubiquitination, reducing its expression. AARS1 mediates lactylation at lysine 565, while disrupted binding to LDHA further promotes lactylation, suppressing YTHDC1. This downregulation enhances PTPN22 mRNA stability, leading to NLRP3 dephosphorylation and activation, which exacerbates inflammation ...
Feng Zhang, Linghua Zeng, Kunkun Zou, Keying Lin, Fangting Yao, Jinglun Song, Shumeng Zhang, Hanshu Feng, Zhichao Yang, Chunlei Wang, Hongtao Diao, Xue Kong, Tengfei Pan, Joonki Kim, Tianqi Duo, Linqiang Li, Yu Bian   +16 more
wiley   +1 more source

The Uses of Drones in Case of Massive Epidemics Contagious Diseases Relief Humanitarian Aid: Wuhan-COVID-19 Crisis

, 2020
Mario Arturo Ruiz Estrada
openalex   +1 more source

The association between ambient temperature and sperm quality in Wuhan, China [PDF]

, 2020
Xiaochen Wang, Xinling Tian, Bo Ye, Yi Zhang, Xiaotong Zhang, Shichun Huang, Cunlu Li, Simin Wu, Rui Li, Yuliang Zou, Jingling Liao, Jing Yang, Lu Ma   +12 more
openalex   +1 more source

Redefining Dendritic Cell Vaccines: Synergistically Co‐priming DC and B Cells With Nanoparticles Loading Whole Cell Antigens Maximizes the Efficacy of DC Vaccines

Advanced Science, EarlyView.
Dendritic cells (DC) vaccine is an important type of vaccines. However, the limited efficacy of DC vaccines hinders their widely application. This study redefines DC vaccines and provides a new DC‐BC vaccine that have much better therapeutic efficacy.
Xiangxiang Xu, Xianlan Chen, Jin Wang, Yuhan Liu, Sidra Mustafa, Lu Diao, Rongrong Zhao, Haiyang Chi, Kang Hu, Jiashan Zhu, Jun Zhao, Mi Liu   +11 more
wiley   +1 more source

Distribution of Gc Types in Wuhan [PDF]

Fayixue Zazhi, 1985
The distribution of group-specific component(G) types was examined by disc electrophoresis from 508 unrelated residents in Wuhan. Discontinuous buffer system was used in this investigation. The polyacrylamide concentration used for separating gel was 9%,
LONG YANG YANG QING-EN(DEPARTEMENT OF FORENSIC MEDICINE;WUHAN MEDICAL COLLEGE;WUHAN)
doaj